WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...

The UPR reprogrammes transcription to enhance the capacity of the ER to cope with misfolded proteins, but also affects the function of the ... or protein kinase RNA (PKR)-like ER kinase (PERK).

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

SignalChem Biotech provides diverse recombinant Tau proteins for research, helping advance tau-targeted therapies that may ...

In particular, SCFA modulate mucosal immune functions. The antimicrobial cathelicidin LL-37 is expressed by colon ... In addition, intracellular signalling pathways such as MEK-ERK ...

Mayo Clinic Comprehensive Cancer Center experts highlight breast cancer research that may reduce or eliminate the need for chemotherapy and endocrine treatments and may allow for shorter and less ...

Data demonstrate potential superiority of a targeted protein degradation strategy compared to kinase inhibition for both BTK ...

News on Inhibikase's promising treatments for PAH and Parkinson's Disease, supported by FDA approval and substantial funding.

PEG-MGF, or polyethylene glycol-modified mechanogrowth factor, is a peptide that has garnered attention in scientific ...

In line with the proposal for amending the warning statement of Insulin Lispro Ultrarapid Injection 100 IU & 200 IU, the ...