Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

Immunostaining corroborated that aneuploidy triggers proteotoxic stress, autophagy, p53-signalling, and apoptosis independent from DNA ... gene sets to be positively enriched while oxidative ...

SURF6, an intrinsically disordered protein, plays a crucial role in ribosome biogenesis and cellular proliferation ... our examination has scrutinized the role of LLPS in regulating cell viability via ...

Previous studies in other models have shown that genotoxic and proteotoxic stresses arising from aneuploidy lead to the activation of the p53 pathway and autophagy, which helps eliminate cells with ...

We report that stress-induced nuclear inclusions related to the nucleolus are eliminated upon stress alleviation during the recovery period. This process is independent of autophagy/lysosome and ...

Post-translational modifications (PTMs) increase the functional diversity of the proteome by the covalent attachment of chemical groups or proteins to diverse cellular protein targets. These ...

The high emissions intensity of terrestrial animal source food (TASF) and projected increasing demand in low- and middle-income countries (LMIC) have spurred interest in the development of animal-free ...

Research in his lab focusses on autophagy-mediated cellular quality control mechanisms ... He joined INSERM and set up his group at IECB / ARNA in Bordeaux in 2013, where he studies ribosomes, ...