12月9日晚，张家界天门山出现雨夹雪的天气。10日上午，海拔1500多米的天门山山顶温度降至零度以下，出现大面积的雾凇奇观。地面也出现了结冰的现象，部分游道进行了临时关闭。目前，景区的索道正常运行，不影响游客正常进山游览，游客朋友们上山要做好防寒防滑措施。（来源：华声在线 视频：向希）On the evening of ...

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为了设计能够特异性靶向中枢神经系统（CNS）的细胞，我们鉴定了细胞外中枢神经系统特异性抗原，包括中枢神经系统细胞外基质的成分和在神经元或胶质细胞上表达的表面分子。 用于检测这些抗原的合成Notch受体被用于编程改造T细胞，仅在大脑中诱导不同有效载荷的表达。诱导嵌合抗原受体表达的CNS靶向T细胞有效清除了原发性和继发性脑肿瘤，而不损害脑外交叉反应细胞。 此外，局部递送免疫抑制细胞因子白介素—10的中 ...