Keywords: Interleukin-1b (IL-1b), Interleukin-6 (IL-6), C-reactive Protein (CRP), Inflammatory Pathways, Cardiovascular Diseases, Drug Development, Clinical Trial Design, Therapeutic Efficacy, ...

In one new study, researchers built an artificial neural network using proteins and used it to classify signals in cells. (Science 2024, DOI: 10.1126/science.add8468) Generally, when neural ...

The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Cancer Institute, Jiangxi Cancer Hospital, Nanchang 330029, Jiangxi Province, China ...

In this study, we aim to investigate the role of protein kinases G (PKG) as downstream mediators of sGC–cyclic guanosine ... as an attempt to compensate for the decreased signalling through the ...

The authors use deep mutational scanning to assess the effect of all possible protein-coding variants in MC4R ... should be broadly applicable to GPCRs and other drug target classes that function in ...

The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are ...