Aurora kinases are a family of serine/threonine kinases that play crucial roles in cell division and are increasingly recognized for their involvement in cancer progression and treatment resistance.
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...
Objectives Casein kinase II (CK2) is a constitutively active serine/threonine protein kinase that plays a key role in cellular transformation and tumorigenesis. The purpose of the study was to ...
Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas nonreceptor tyrosine kinases and serine/threonine protein kinases function throughout ...
uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...
RIPK1 – or receptor-interacting serine/threonine-protein kinase 1 – is thought to play a role in regulating the immune system, and has been a target for programmes both in inflammatory ...