TR-FRET(Time-Resolved Fluorescence Resonance Energy Transfer,时间分辨荧光共振能量转移)是一种用于研究分子间相互作用的生物物理技术。它结合了两种技术:荧光共振能量转移(FRET)和时间分辨荧光(TRF,Time-Resolved Fluorescence)。 荧光共振能量转移是一种物理现象,其中 ...
A randomized, phase 2 clinical trial shows that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer ...
KRAS G12C抑制剂领域已经出现了百舸争流的局面。 同时,KRAS G12D抑制剂也开始小试牛刀,为这个靶点开辟更广泛的治疗领地。除此之外,泛KRAS抑制剂 ...
2024年10月25日,Revolution Medicines官网公布了其KRAS G12D抑制剂RMC-9805单药治疗晚期胰腺导管腺癌(PDAC)患者的初步疗效数据。这些结果于2024年10月25日在巴塞罗那举行的EORTC-NCI-AACR分子靶点和癌症治疗研讨会的新口头会议上公布。 KRAS G12D是胰腺导管腺癌中最常见的KRAS ...
This is generally a well-designed and carefully conducted study that is likely to be of interest to many both inside and outside of the field of lung tumorigenesis and normal lung development and ...