aArthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada bProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada ...

Furthermore, RNA-seq analyses of BCP-treated HepG2 cells identified 433 protein-coding DEGs. Integrative analyses revealed five BCP-targeted DEGs regulating the MAPK signaling pathway. Among these ...

He hand-grinds, shapes and custom crafts a set of forged, muscle-back blades that are uniquely yours. A set that’s one-of-one, if you will. We’ve shared some insight into P53 with you before and it’s ...

PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that bind to the PIWI subclass of the Argonaute protein family and are essential for maintaining germline integrity. Initially discovered in ...

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这种由铜离子介导的细胞死亡过程被称为铜死亡（cuproptosis）【1】。肿瘤抑制因子p53在维持细胞代谢稳态方面发挥重要作用。2023年，周祥团队提出观点，认为铜死亡可能是一种由p53调节的代谢性细胞死亡方式【2】。首先，p53抑制糖酵解过程。例如，该团队早期 ...

This work is licensed under a Creative Commons Attribution 4.0 International License . Missense-type p53 mutations have shown to acquire novel oncogenic roles through gain-of-function mechanism.

The cohesin complex is essential for sister chromatid cohesion, DNA replication, DNA repair, and genome organization. Three subunits, SMC1A, SMC3, and RAD21, form the core ring-shaped structure of ...