Patients with hematological malignancies have a risk of developing graft-versus-host disease (GVHD) following allogeneic ... targeted elimination of the donor T-cell, the putative effector ...

In addition, in mice with persistent host Langerhans cells, delayed administration of donor T cells resulted in the complete depletion of ... marked (grade 4) skin GVHD (Fig.

To prevent graft rejection and GVHD, many efforts were put on removing the T-cells, which play a key role in immune response, and cause host rejection of donated marrow. However, T-cell depletion ...

While the highest success rates historically have been seen in patients receiving transplants from matched sibling donors, advances in conditioning regimens and T-cell depletion strategies have ...