Comparative Assessment of Surface CD19 and CD20 Expression on B-Cell …
2019年11月13日 · Conclusions: CD19 and CD20 are both highly and consistently expressed in B-cell lymphomas. While CD20 has a higher average density of surface molecules per tumor cell, CD19 expression is more homogenous and is preserved in small CD20-negative tumor subsets and after anti-CD20 targeted therapy.
What is the difference between the CD19 or CD20 marks of lineages in B ...
CD19 is a less specific marker of B cell lineage; it is expressed on earlier progenitors starting at the pre-B cell stage. CD20 is more robust for naive and mature B cells and is...
B cell depletion therapies in autoimmune disease: advances and ... - Nature
2020年12月15日 · Originally conceived as a method of eliminating cancerous B cells, BCDTs such as those targeting CD20, CD19 and BAFF are now used to treat autoimmune diseases, including systemic lupus...
CD19: a biomarker for B cell development, lymphoma diagnosis …
2012年11月29日 · CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling.
Bispecific antibodies for the treatment of B-cell lymphoma: …
2023年2月2日 · CD19 and CD20 20 are relatively stable cell-surface antigens widely expressed on B cells and have been used as targets for most BsAb currently in development for B-NHL.
CD20 as a gatekeeper of the resting state of human B cells
CRISPR/Cas9-mediated ablation of CD20 in resting B cells resulted in relocalization and interaction of the IgM-class B cell antigen receptor with the coreceptor CD19. This receptor rearrangement led to a transient activation of B cells, accompanied by the internalization of many B cell surface marker proteins.
Levels of expression of CD19 and CD20 in chronic B cell leukaemias
RESULTS: CD19 and CD20 ABC values in leukaemic B cells differed from those of normal blood B lymphocytes. The results identified distinct profiles of CD19 and CD20 expression in the various types of B cell leukaemias.
Bispecific CAR-T cells targeting CD19/20 in patients with ... - Nature
2024年8月7日 · The efficacy and safety of autologous CD19/20 CAR-T cells in eleven R/R B cell NHL adult patients were evaluated in an open-label, single-arm trial.
B cell-based therapies in CNS autoimmunity: differentiating CD19 …
2018年3月21日 · Summary of CD19 and CD20 expression during B cell development. CD19 expression is observed on earlier-stage B cells than is CD20. In addition, CD19 expression is found to persist on late-stage antibody-secreting B cells (plasmablasts and plasma cells) after CD20 expression has been lost.
Trispecific CD19-CD20-CD22–targeting duoCAR-T cells ... - Science
In this study, we developed trispecific duoCAR-T cells that target the B cell antigens CD19, CD20, and CD22. In antigen-replete in vivo models of B cell NHL and ALL, the trispecific duoCARs were equally or more potent than their monoCAR or tandem CAR …
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