The epidermal growth factor receptor variant III (EGFRvIII ... - PubMed
Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant …
Epidermal growth factor receptor (EGFR) and EGFRvIII in …
While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here, we discuss signaling pathways mediated by EGFR/EGFRvIII, current therapeutics, and novel strategies to target EGFR / EGFRvIII -amplified GBM.
EGFRvIII: An Oncogene with Ambiguous Role - PMC - PubMed …
EGFRvIII increases mismatch repair protein expression and is therefore a predictive marker for temozolomide response in O6-methylguanine-DNA methyltransferase negative glioblastoma cells and tumors. Neuro-Oncology. 2016;18(suppl_6):p. vi208. doi: 10.1093/neuonc/now212.879.
Current Therapeutic Advances Targeting EGFR and EGFRvIII in ...
Epidermal growth factor receptor (EGFR) and EGFRvIII analysis is of current interest in glioblastoma – the most common malignant primary CNS tumor, because of new EGFRvIII vaccine trials underway.
Epidermal Growth Factor Receptor Variant III (EGFRvIII ... - PubMed
2017年11月15日 · Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in <i>EGFR</i>-amplified glioblastoma patients and changes in EGFRvIII expression in recurrent versus primary gliob</span> …
EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 …
We document coexpression of EGFR and EGFRvIII in human tumors, identify a cell-intrinsic role for coexpression in vitro and in vivo, and demonstrate that EGFR and EGFRvIII cooperate to phosphorylate STAT proteins, promoting malignant progression.
Structural insights into the role and targeting of EGFRvIII
2024年9月5日 · To shed light on the role of EGFRvIII and its potential as a therapeutic target, we determined X-ray crystal structures of a monomeric EGFRvIII extracellular region (ECR). The EGFRvIII ECR resembles the unliganded conformation of EGFR, including the orientation of the C-terminal region of domain II.
EGFRvIII: the promiscuous mutation - PMC - National Center for ...
2016年7月4日 · EGFRvIII is known to contain a free cysteine that is not present in untruncated EGFR, and we have shown that this cysteine is critical for the activation of EGFRvIII and for its ability to transactivate other receptor tyrosine kinases such as c-Met. 6 Uncovering the role of this cysteine in the EGFRvIII–OSMR complex may provide new ...
Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in
2017年11月14日 · Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about half of these tumors express the EGFRvIII variant.
2024年6月21日 · To shed light on the role of EGFRvIII and its potential as a therapeutic target, we determined X-ray crystal structures of a monomeric EGFRvIII extracellular region (ECR). The EGFRvIII ECR resembles the unliganded conformation of EGFR, including the orientation of the C-terminal region of domain II.
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