Venlafaxine (Effexor) similar in structure to Tramadol
2004年2月4日 · It has a similar chemical structure to the opioid derivative tramadol, and has the tertiary amine functional group necessary for µ-opioid receptor recognition (cf. lefetamine), and indeed, Venlafaxine acts as an agonist at the mu-opioid receptor.
Tramadol/Carisoprodol Combination (Safe? Doses?) - Bluelight.org
2010年6月24日 · Another theory is that the structure is more closely related to cyproheptadine, an antagonist at histamine H1 receptors, muscarinic acetylcholine receptors, and 5-HT2A serotonin receptors. Tram is my DOC and I'm always looking to add to it but after reading about this combo I tossed out the 90 cyclo's I had laying around - just so I wouldn't be ...
Opioids codeine or tramadol? - bluelight.org
2023年10月28日 · Tramadol all the way!! 200-400mg spread over the course of an hour & you'll be feeling good for 6-8hrs (depending on your tolerance). It also depends on if you're a good metabolizer for tramadol or not. Tramadol does fuck all for some people. But for people with the right liver enzymes, tramadol can absolutely beat the hell out of codeine any day.
Opioids - Tramadol Megathread - Bluelight.org
1999年11月3日 · Tramadol is a fully synthetic opioid unlike opiates like Morphine or Codeine which are found in the poppy plant ( Papaverus Somniferum ) or semi-synthethic opioids like Diamorphine (Heroin) . Tramadol acts by binding to the μ-opioid receptor of the neuron and is also a serotonin–norepinephrine reuptake inhibitor.
Tramadol fakes? - Bluelight.org
2003年3月25日 · Tramadol fucks with you physically and mentally and the combo of the 2 was sheer hell. And then I tried to ease the withdrawal with vodka which helped some but then it came back worse. Resulting in a 97 day rehab stint which was a wise choice.
Opioids - O-DSMT Megathread | Bluelight.org
2002年10月18日 · The pharmacological profile of Tramadol is far more complex than that of plain o-desmethyl. Tramadol itself has a strong affinity for SERT but weak affinity for NET and opioid receptors. Both O-desmethyl isomers have a negligible (none?) affinity for SERT and a high affinity for Mu and, in the case of M1 (forgot which isomer this one is), a ...
Opioids - Tramadol high - Bluelight.org
2018年9月26日 · The ssri properties of tramadol are one of the reasons i was wondering if you are on any antidepressants @ South_Darkens. Im partly interested to see if you'r on any, if you feel they help at all. Also i'm concerned that if you are any. That tramadol + antidepressants can cause Serotonin syndrome. Feel free to reply. There is no judgment here.
Tramadol (Various Doses) - Experienced - Bluelight.org
2010年6月5日 · tramadol seems to be a very idiosyncratic drug and i feel it's effects are hard to calculate. there were times in my life, when I felt that (o-desmethyl) tramadol is a useless compound (used it a couple of times to to get boring things done, like cleaning the house. "it's so useless I don't even wanna take it to go out"); then there were some experiences when I really …
Tramadol - Bluelight.org
2005年10月7日 · Keeping your mind occupied with tasks is a great way to get outta that habituation, we all need structure in our lives so that we don't have enough time to get to fucked. Also eat healthy drink heaps of water and exercise, the normal stuff a lot of people forget there is a lot connected between you feeling good and eating healthy, maybe then ...
Opioids Tianeptine vs Tramadol opioid binding affinity.
2018年8月29日 · I was a hardcore tramadol addict for over 10 years. I went through tramadol withdrawal every month, every year, for over a decade. With that said, my first go with tianpetine was tianpetine sulfate from a well respected vendor. My experience was completely null all the way up to 400mg of tianeptine sulfate. Absolutely no opioid effects whatsoever.