Growth differentiation factor 11: a “rejuvenation factor” involved in ...
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength.
Aging and GDF11: What we know | Harvard Stem Cell Institute …
The cause of this anti-aging phenomenon remained a mystery until May 2013, when Wagers, PhD, and cardiologist Richard Lee, MD, found that a protein in the blood of young mice, called GDF11, was able to quickly reverse symptoms of heart failure in older mice.
GDF11 Gene - GeneCards | GDF11 Protein | GDF11 Antibody
2024年12月25日 · GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Vertebral Hypersegmentation And Orofacial Anomalies and Orofacial Clefting Syndrome. Among its related pathways is …
GDF11 growth differentiation factor 11 [ (human)] - National …
2024年11月27日 · GDF11 Is a Novel Protective Factor Against Vascular Calcification. Pathophysiological levels of GDF11 activate Smad2/Smad3 signaling and induce muscle atrophy in human iPSC-derived myocytes. GDF11 inhibits adipogenesis and improves mature adipocytes metabolic function via WNT/beta-catenin and ALK5/SMAD2/3 pathways.
GDF11 slows excitatory neuronal senescence and brain ageing by …
2023年11月17日 · In vitro GDF11 deletion causes cellular senescence in Neuro-2a cells. Mechanistically, GDF11 deletion induces neuronal senescence via Smad2-induced transcription of the pro-senescence factor p21....
Biochemistry and Biology of GDF11 and Myostatin:
2016年4月1日 · GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues, whereas myostatin is a well-described negative regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes.
Role of growth differentiation factor 11 in development, …
In this review, we describe the GDF11 signaling pathway and its potential role in development, physiology and disease. Growth differentiation factor (GDF11), also called as bone morphogenetic protein 11 (BMP11) belongs to the transforming growth factor-β (TGF-β) superfamily.
GDF11: An emerging therapeutic target for liver diseases and …
Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), has been identified as a key player in various biological processes, including embryonic development, aging, metabolic disorders and cancers. GDF11 has ...
GDF11 growth differentiation factor 11 - NIH Genetic Testing …
2024年12月10日 · Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells. Growth differentiation factor 11 supports migration and sprouting of endothelial progenitor cells.
Novel insights into the pleiotropic health effects of growth ...
2024年9月6日 · Growth Differentiation Factor 11 (GDF11) is a circulating member of the transforming growth factor β (TGF-β) superfamily that has essential roles in mammalian development. Genetic knockout studies have revealed the far-reaching effects of GDF11 on the developing embryo.
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