2024年12月20日 · Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein. This protein is made in the soft, blood-producing tissue in the center of bones.

2021年12月10日 · Quantitative immunoglobulins showed normal IgG, immunoglobulin A (IgA), and immunoglobulin M (IgM) levels. Also, serum free light chains (FLCs) were evaluated, and they showed normal levels.

IgM MGUS – IgM MGUS accounts for approximately 15 percent of MGUS cases. It is considered separately from the non-IgM MGUS because it has the potential to progress to smoldering Waldenström macroglobulinemia and to symptomatic Waldenström macroglobulinemia, and less often to lymphoma or AL amyloidosis.

Monoclonal gammopathies are conditions in which abnormal proteins are found in the blood. The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance (MGUS). MGUS usually causes no symptoms. Diagnosis is often done with a lab test called protein electrophoresis.

Nearly 80% of MGUS cases are derived from a non-IgM isotype (IgG or IgA), with IgG the most frequently found in population-based studies [4]. In the absence of myeloma-related symptoms, non-IgM MGUS is characterized by an M-protein lower than 30 g/L and less than 10% of plasma cells in bone marrow.

2019年4月1日 · An M protein may consist of an intact immunoglobubin (Ig) molecule — i.e., two light chains and two heavy chains (most commonly IgG type followed by IgA and IgM) — or a light chain only (kappa or lambda).

What is monoclonal gammopathy of undetermined significance (MGUS)? Monoclonal gammopathy of undetermined significance (MGUS) is a blood disorder that affects plasma cells in your bone marrow. Most of the time, M proteins don’t cause issues and most people with MGUS don’t have symptoms.

There are five types of paraprotein: IgG, IgA, IgM, IgD and IgE. Ig stands for immunoglobulin, another name for paraprotein. There are two types of light chain: kappa (κ) and lambda (λ). So when you get an MGUS diagnosis, you might be told the type is IgG lambda, for example.

Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common pre-malignant disorders and affects approximately 3.5% of the population over 50 years of age. 1–3 IgG and IgA MGUS are defined by a M-protein less than 30 g/L, bone marrow (BM) plasma cell percentage less than 10%, and absence of signs or symptoms related to mul...

2023年8月3日 · Monoclonal gammopathy of undetermined significance (MGUS) is the most common of a spectrum of diseases called plasma cell dyscrasias. The term MGUS denotes the presence of a monoclonal...