p53 - Wikipedia
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]
Tumor Suppressor p53: Biology, Signaling Pathways, and ...
TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …
The p53 tumor suppressor protein - Genes and Disease - NCBI ...
In the cell, p53 protein binds DNA, which in turn stimulates another gene to produce a protein called p21 that interacts with a cell division-stimulating protein (cdk2). When p21 is complexed with cdk2 the cell cannot pass through to the next stage of cell division.
Targeting p53 pathways: mechanisms, structures and advances ...
2023年3月1日 · The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, and is...
The Tumor Suppressor p53: From Structures to Drug Discovery
Concerted action of folded and intrinsically disordered domains of the highly dynamic p53 protein provides binding promiscuity and specificity, allowing p53 to process a myriad of cellular signals to maintain the integrity of the human genome.
Role of p53 in Cell Death and Human Cancers - PMC
Upon DNA damage, p53 is induced at protein level and exerts its transcriptional as well as pro-apoptotic function in association with chemical modifications such as phosphorylation and acetylation [2-5]. p53 is phosphorylated at Ser-15, Ser-20 …
The p53 Gene and Cancer - BioInteractive
2003年2月28日 · This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. The Click & Learn presents different types of genes that, when mutated, contribute to cancer, including oncogenes, tumor suppressor genes, and DNA repair genes.