Targeted protein degradation: mechanisms, strategies and …
2022年4月4日 · Targeted protein degradation (TPD), via the proteasomal and lysosomal pathways, represent a novel tool to explore cellular pathways and a promising therapeutic …
Targeted protein degradation: from mechanisms to clinic
2024年4月29日 · Here, we review the current landscape of targeted protein degradation approaches and how they have parallels in biological processes. We also outline the ongoing …
Targeted protein degradation: advances in drug discovery and …
2024年11月6日 · Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic …
Targeted protein degradation: current molecular targets, …
2024年11月1日 · Targeted protein degradation (TPD) has revolutionized drug discovery by selectively eliminating specific proteins within and outside the cellular context. Over the past …
Targeted Protein Degradation: Advances, Challenges, and …
2023年8月21日 · Targeted Protein Degradation (TPD) A biomedical research strategy that aims to selectively eliminate specific proteins from cells for therapeutic applications, often using …
Targeted Protein Degradation: Principles and Applications of the ...
Most cellular proteins are selectively degraded by the proteasome via ubiquitination. Moreover, the ubiquitin–proteasome system is a critical process for maintaining protein homeostasis.
Targeted protein degradation: A promise for undruggable proteins
2021年7月15日 · In this review, we discuss the progress and evolution of the TPD field, the breadth of the proteins targeted by PROTACs and the biological effects of their degradation.
Targeted Protein Degradation (TPD) for Immunotherapy: …
2024年7月11日 · Targeted protein degradation or TPD, is rapidly emerging as a treatment that utilizes small molecules to degrade proteins that cause diseases. TPD allows for the selective …
Targeted protein degradation: mechanisms, strategies and
2022年4月4日 · In addition to PROTAC, many different targeted protein degradation (TPD) strategies including, but not limited to, molecular glue, Lysosome-Targeting Chimaera …
Targeted Protein Degradation
2024年12月17日 · Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic …