Concanavalin A as a promising lectin-based anti-cancer agent: …
2022年10月26日 · Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism.
Structural and biochemical analyses of concanavalin A circular ...
Concanavalin A (conA) is a seed lectin of the jack bean plant (Canavalia ensiformis); it is a noncatalytic protein that binds specific carbohydrates (monomers and oligomers of mannose and glucose) reversibly and with high specificity and moderate affinity (Lis and Sharon, 1998).
T Cell Activation via Concanavalin A - Thermo Fisher Scientific
Concanavalin A (con A) is an antigen-independent mitogen and can be used as an alternative T cell stimulus. This lectin is frequently used as a surrogate for antigen-presenting cells in T cell stimulation experiments. Concanavalin A irreversibly binds to glycoproteins on the cell surface and commits T cells to proliferation.
Concanavalin A - an overview | ScienceDirect Topics
Concanavalin A (Con A), the most studied of the plant lectins, first isolated and crystallized by Sumner and Howell (1936), seems to be the most nutritionally important toxic and antinutritional factor in the raw unprocessed jackbean seed.
Concanavalin A - PubChem
Concanavalin A is a potent lymphocyte mitogen and a stimulator of matrix metalloproteinases, thereby exhibiting immunostimulatory effects. It is used in the characterization and purification of glycoproteins.
Structure and function of concanavalin A - PubMed
In conjuntion with our studies on the cell surface and mitosis, we have determined the amino acid sequence and three-dimensional struction of concanavalin A (Con A), the mitogenic lectin from the jack bean.
Concanavalin A - an overview | ScienceDirect Topics
Concanavalin A (Con A) is a broadly selective lectin that favors glycans presenting α-mannose-containing cores, such as those found in many N-glycans; it can be useful for separating N-glycosylated proteins from O-glycosylated proteins in a sample. 16,18 At least two terminal [Man(α1-; Glc(α1-; GlcNAc(α1-]- or 2-substituted [-2)Man(α1-; -2 ...
Structure and Function of Concanavalin A | SpringerLink
In conjuntion with our studies on the cell surface and mitosis, we have determined the amino acid sequence and three-dimensional struction of concanavalin A (Con A), the mitogenic lectin from the jack bean.
Concanavalin A, from an old protein to novel candidate anti
In this review, we mainly focus on analyzing the anti-tumor activities of Concanavalin A (ConA), the first and most typical representative of legume lectin family, and its related mechanisms of cell death implicated in apoptosis and autophagy.
Concanavalin A (Con A) is one of a group of plant proteins, termed lectins, that has been a particularly useful probe in studies of cell surface membrane dynamics and cell division in lymphocytes (1, 2). Previous structural studies have shown that Con A’ at physiological pH is a tetramer of identical
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