The molecular mechanisms of copper metabolism and its roles …
In multicellular organisms, copper metabolism involves uptake, distribution, sequestration, and excretion, at both the cellular and systemic levels. Mammalian enterocytes take in bioavailable copper ions from the diet in a Ctr1-dependent manner.
Copper Metabolism - an overview | ScienceDirect Topics
Copper plays a fundamental role in aerobic metabolism, but its role is double-edged, given its toxicity. Our understanding of copper metabolism in parasites remains rudimentary, despite its significance in virulence. Here we discuss how parasitic protists control copper homeostasis and show the potential key players identified by our ...
Role of Copper on Mitochondrial Function and Metabolism
This review goes over the copper source, distribution, cellular uptake, and its role in mitochondrial function, metabolic reprograming, and cancer biology, linking copper metabolism with the field of regenerative medicine and cancer.
Copper homeostasis and cuproptosis in health and disease
2022年11月23日 · Here, we summarize our current knowledge regarding copper metabolism, copper-related disease, the characteristics of cuproptosis, and the mechanisms that regulate cuproptosis.
The molecular mechanisms of copper metabolism and its roles …
2020年6月7日 · In multicellular organisms, copper metabolism involves uptake, distribution, sequestration, and excretion, at both the cellular and systemic levels. Mammalian enterocytes take in bioavailable copper ions from the diet in a Ctr1-dependent manner.
Copper Metabolism and Cuproptosis: Molecular Mechanisms and …
Recent studies suggest that copper can trigger a specific form of cell death, namely, cuproptosis, which is triggered by excessive levels of intracellular copper. Cuproptosis induces the aggregation of mitochondrial lipoylated proteins, and the loss of iron-sulfur cluster proteins.
The mechanism of copper homeostasis and its role in disease
2023年8月8日 · Here, we review the process of copper metabolism, explore the underlying mechanisms of cuprotosis, and provide novel ideas for diagnosing and treating disorders of copper metabolism associated with copper toxicity, with a …
Copper Metabolism - an overview | ScienceDirect Topics
Copper is an essential element that is required for a variety of important cellular functions. Since not only copper deficiency but also excess of copper can seriously affect cellular functions, the cellular copper metabolism is tightly regulated. In brain, astrocytes appear to play a pivotal role in the copper metabolism.
Copper Metabolism and Cuproptosis: Molecular Mechanisms and …
2024年2月10日 · Recent studies suggest that copper can trigger a specific form of cell death, namely, cuproptosis, which is triggered by excessive levels of intracellular copper. Cuproptosis induces the aggregation of mitochondrial lipoylated proteins, and the …
Copper Metabolism - an overview | ScienceDirect Topics
Copper acts as an essential cofactor in enzymes, including dopamine-β-hydroxylase, ascorbic acid oxidase, cytochrome oxidase, superoxide dismutase, elastase, lysyl oxidase, tyrosinase, and ceruloplasmin. Copper is available in many foods, including shellfish, liver, lentils, nuts, sunflower seeds, and chocolate.
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