What is fibrous dysplasia? Fibrous dysplasia is a long-term (chronic) problem in which scarlike tissue grows in place of normal bone. It is not cancer. It often results in one or more of these: Bone deformity. Brittle bones. Pain. Uneven growth of bones. Any bone can be affected. More than one bone can be affected at any one time.

Fibrous dysplasia is a very rare [2] nonhereditary genetic disorder where normal bone and marrow is replaced with fibrous tissue, resulting in formation of bone that is weak and prone to expansion. As a result, most complications result from fracture, deformity, functional impairment, pain, and the impingement of nerves. [3] .

Fibrous dysplasia is a benign (noncancerous) bone condition in which abnormal fibrous tissue develops in place of normal bone. As these areas of fibrous tissue grow and expand over time, they can weaken the bone—causing it to fracture or become deformed.

Fibrous dysplasia can make your bones fragile and more susceptible to bone fractures (broken bones). It can affect any bone in your body, but most commonly affects your: Thigh bone (femur). Shin bone (tibia). Ribs. Skull (including your facial bones). Upper arm (humerus).

Fibrous dysplasia happens when a gene mutates (changes) while the baby is developing in the womb. The changes in the gene cause bone-forming cells to fail to mature. Instead, they produce abnormal fibrous tissue in certain bones.

2024年9月30日 · Fibrous dysplasia is a developmental abnormality caused by a Gs alpha protein mutation that leads to failure of the production of normal lamellar bone and arrest as woven bone. The condition usually presents in patients who are less than 30 years of age with an asymptomatic lesion that is found incidentally on radiographs.

Fibrous dysplasia happens when a bone is replaced with other tissues. Bones may become weak, oddly shaped, or broken. Learn more about this rare disease.

2023年7月24日 · Fibrous dysplasia is a typically benign bone lesion characterized by intramedullary fibro-osseous proliferation secondary to altered osteogenesis. The polyostotic form often presents in childhood. Malignant transformation is rare, and remote radiation therapy has been reported as a risk factor.

2020年1月2日 · The trabeculae in fibrous dysplasia are composed of woven bone with various phases of mineralization. Mature lamellar bone can be seen at the periphery but should not be part of the lesion itself.

Fibrous dysplasia happens when abnormal fibrous (scar-like) tissue replaces healthy bone. The disease can affect any bone in the body. Symptoms of fibrous dysplasia can include bone pain, misshapen bones, and broken bones.