2020年9月15日 · The prevalence of postmortem histological osteomalacia histologically is as high as 25% in adult Europeans have been reported. However, the true global incidence of osteomalacia remains vastly underestimated. At-risk individuals include those with dark skin, limited sun exposure, low socioeconomic status, poor diet, and frequent wearers of full ...

With the widespread use of measurement of bone mineral density to detect, diagnose, and monitor therapy in the management of osteoporosis, bone histomorphometry has largely been relegated to research settings and academic pursuits.

Three categories of histologic features of osteomalacic bone are proposed: (1) increased osteoid, elevated osteoblast and osteoclast numbers and marrow fibrosis; (2) increased osteoid and osteoblast numbers, and (3) increased osteoid associated with few osteoblasts.

2021年6月17日 · Osteomalacia is a metabolic bone disease where defective mineralization results in a large amount or unmineralized osteoid. Diagnosis is made based on a thorough evaluation of serum labs, clinical features, and radiographic findings.

2016年10月10日 · We performed a bone histomorphometric analysis in two patients demonstrating Fanconi syndrome with hypophosphatemia, adefovir-related bone disease and chronic hepatitis B infection. Both patients had osteomalacia, but showed two …

2024年1月1日 · Osteomalacia is not a radiological diagnosis but diagnosed on histomorphometry of bone biopsy, and reflects defective mineralization of the preformed osteoid. Both conditions, however, have typical clinical and biochemical features that aid in diagnosis.

Osteomalacia, also called adult rickets, 46,72 is typified by the presence of poor bone quality. Osteomalacia is more accurately described as a group of entities that can produce similar, yet nonspecific, radiographic changes. The clinical and biochemical profile of osteomalacia varies.

2018年3月17日 · With the widespread use of measurement of bone mineral density to detect, diagnose, and monitor therapy in the management of osteoporosis, bone histomorphometry has largely been relegated to research settings and academic pursuits.

Osteomalacia (soft bone) is the skeletal manifestation of various metabolic abnormalities which result in defective bone formation 1,2,14,16, 33,34,39: the lag time between bone formation and mineralization is increased, generally by more than 100 days.

2023年6月16日 · Osteomalacia was diagnosed on histopathological analysis in 19/72 (26.7%), and 54/72 (75.0%) of all cases fulfilled b-OM criteria. In the histologic evaluation, osteoid seam width, osteoid surface, and osteoid volume were 28.5 µm, 25.6, and 12.1%, respectively.