Piritramide [3] (R-3365, trade names Dipidolor, Piridolan, Pirium and others) is a synthetic opioid analgesic (narcotic painkiller) that is marketed in certain European countries including: Austria, Belgium, Czech Republic, Slovenia, Germany and the Netherlands. [4]

2016年10月20日 · Piritramide is a synthetic opioid used in the treatment of severe pain. Piritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting.

Piritramide | C27H34N4O | CID 9331 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Piritramide is a synthetic opioid and a µ-receptor agonist. Thus, the analgesic effect is due to binding to µ-receptors in the CNS. After intravenous administration, the onset of analgesia is only 1-2 minutes, possibly related to its large lipophilicity.

Results: Piritramide is a strong opioid that can only be administered parenterally. After intravenous injection it is effective after 17 min with pain relief lasting for up to 6 h. It is metabolized in the liver to inactive compounds, which is advantageous compared to morphine where active metabolites can accumulate in patients with renal failure.

Piritramide is most commonly prescribed i.m. or i.v. for postoperative analgesia. It is used successfully for patient-controlled analgesia in adults 14 and more recently in chil-dren. Piritramide has potency 0.65 to 0.75 times that of morphine.

Chemical formula: C₂₇H₃₄N₄O Molecular mass: 430.585 g/mol PubChem compound: 9331. Piritramide is a pure µ-opioid receptor agonist, which has a slightly less analgesic potency than morphine.

Piritramide Respiratory. When piritramide (mean dose 64 micrograms/kg) was given to 39 neonates and infants for postoperative analgesia, respiratory depression occurred in one case [157 c].

Piritramide is a pure µ-opioid receptor agonist, which has a slightly less analgesic potency than morphine. Analgesia results from activation of the µ-opioid receptors in the spine and the higher pain centres such as the thalamus and cerebral cortex, thereby raising the pain threshold and the sensitivity to pain.

Piritramide (R-3365, trade names Dipidolor, Piridolan, Pirium and others) is a synthetic opioid analgesic (narcotic painkiller) that is marketed in certain European countries including: Austria, Belgium, Czech Republic, Germany and the Netherlands. [2]