Salvinorin A - Drugs-Forum
2003年1月14日 · salvinorin A is deactivated before entering the blood stream. When pure salvinorin A is encapsulated and swallowed it is inactive even at relatively large doses, but when absorbed through the oral mucosa or vaporized and inhaled is extremely active. It is likely that if salvinorin A were administered by injection, it would prove to be
Oral use - Salvinorin A solubility in glycerin - Drugs-Forum
2007年10月31日 · Hello. Some people have asthma and cannot smoke extract/leaves due to irritation of lungs. It has been stated elsewhere that salvinorin A can be extracted to a crystal state and less then 2mg can be quite an experience. Is there a chance of extracting salvinorin A from an extract to the crystal state and then suspending in a small vial of glycerin?
Experiences - Salvinorin B Ethoxymethyl Ether - Drugs-Forum
2006年1月8日 · Salvinorin A acts at the kappa opioid receptor (Roth et al. 2002), and since most previously known potent opioids have been alkaloids, not diterpenoids, this discovery has excited scientists considerably. In recent years, over a hundred derivatives of salvinorin A have been synthesized in hopes of producing new medicines (Prisinzano & Rothman ...
Herkinorin: Psychedelic Opioid (Salvinorin analog) - Drugs-Forum
2006年12月14日 · Unlike Salvinorin A which is a selective κ-opioid agonist with no significant μ-opioid receptor affinity, herkinorin is a μ-opioid agonist with more than 100x higher μ-opioid affinity and 50x lower κ-opioid affinity compared to Salvinorin A.[2][3] Herkinorin is a semi-synthetic compound made from Salvinorin B, which is found alongside ...
Extraction - Salvinorin A - Drugs-Forum
2009年8月4日 · Search titles only; Posted by Member: Separate names with a comma. Newer Than: Word Count: Search this thread only ...
Salvinorin A: from natural product to human therapeutics (2006)
2008年8月21日 · The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the kappa opioid receptor (KOR) has been identified, in vitro and in vivo, as its molecular target. The discovery of KOR as the molecular target of salvinorin A has opened up many opportunities for drug discovery and drug development for a number of ...
Opinions - LSD’s power Vs Salvia - Drugs-Forum
2005年11月3日 · If by 'more powerful', you mean 'active at a lower dose', then yes, LSD is more powerful than salvinorin-A. LSD is the reason the qualifier 'natural' is inserted into that claim about salvinorin-A's potency. As for subjective strength, there's no criterion by which it would be possible to directly compare any two experiences.
Pure Salvinorin-A - Drugs-Forum
2005年9月30日 · Pure Salvinorin-A Discussion in 'Salvia divinorum' started by kurtisbell, Sep 30, 2005. Sep 30, 2005 #1.
Salvia divinorum - Drugs-Forum
2008年1月27日 · Salvinorin A is a selective kappa opioid receptor agonist. It’s also effective at doses as low as 200ug , making it the most potent naturally-occurring psychoactive compound. Salvinorin A is also currently the only naturally-occuring nonnitrogenous compound to cause hallucinations via the kappa opioid receptor .
Dose Definite overview of salvia divinorum extract doses
2003年1月14日 · I am unusually hard-headed when it comes to most halucinagens, tho the odd activity of salvinorin A hits him well. He beleives that his doses are average but slightly on the large side. that being said, I has never had a truely, wholey positive experience on salvia, despite trying it repeatedly. there really isnt much upside to salvia.