Thioredoxin reductase - Wikipedia
Thioredoxin reductases are enzymes that catalyze the reduction of thioredoxin [1] and hence they are a central component in the thioredoxin system. Together with thioredoxin (Trx) and NADPH this system's most general description is as a system for reducing disulfide bonds in cells.
Thioredoxin Reductase - SpringerLink
2018年1月1日 · Thioredoxin reductase (TrxR; EC 1.8.1.9) is a ubiquitous flavoenzyme which is part of the cell armory against noxious oxidative agents (Gromer et al. 2004). It is a member of the thioredoxin network, comprising Thioredoxin, Trx; TrxR; and a host of enzymes that use Trx as a reductant (e.g., ribonucleotide reductase, peroxiredoxin, etc.).
Thioredoxin Reductase Is a Valid Target for Antimicrobial …
2021年4月15日 · Thioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin, ebselen, shikonin, and allicin.
The mammalian cytosolic thioredoxin reductase pathway acts …
2020年4月30日 · To remove incorrectly oxidised periplasmic thiols, the cytosolic thioredoxin reductase pathway via thioredoxin reduces the membrane protein DsbD, which transfers electrons across the membrane to reduce DsbC that then catalyses disulfide reduction.
The Thioredoxin System of Mammalian Cells and Its Modulators
2022年7月21日 · Multiple antioxidant defense systems have evolved to prevent dangerous ROS accumulation in the body, with the glutathione and thioredoxin/thioredoxin reductase (Trx/TrxR) systems being the most important.
Thioredoxin Reductase, a Redox-active Selenoprotein, Is …
2000年4月1日 · Thioredoxin (Trx) and Trx reductase (TrxR) are redox-active proteins that participate in multiple cellular events, including growth promotion, apoptosis, and cytoprotection. Studies on overexpression of Trx and TrxR in human cancers have indicated a role of these proteins in tumor development.
Mammalian thioredoxin reductase is a well-recognized enzyme for catalyzing the reduction of thioredoxin by NADPH, but its structure, catalytic mechanisms and physiological roles are still under investigation.
The role of the thioredoxin/thioredoxin reductase system in the ...
2018年1月11日 · The main substrate thioredoxin (Trx) is similarly found (as Trx1 and Trx2) in various intracellular compartments, in blood plasma, and is the cell’s major disulfide reductase. Thioredoxin reductase is necessary as a NADPH-dependent reducing agent in biochemical reactions involving Trx.
2004年10月20日 · Thioredoxin reductase (TRX) is a selenoprotein that reduces oxidized protein substrates in an NADPH-dependent process (cf. Fig. 1). The thioredoxins (TX) are a family of small redox active proteins that undergo reversible oxidation/reduction and help to maintain the redox state of cells.
Thioredoxin reductase | Biochemical Journal - Portland Press
2000年2月8日 · The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a conserved -Cys-Val-Asn-Val-Gly-Cys- redox catalytic site, to …
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