The vascular endothelium: the cornerstone of organ dysfunction in ...
2020年6月16日 · In severe SARS-CoV-2 infections, emerging data including recent histopathological studies have emphasized the crucial role of endothelial cells (ECs) in …
Vascular leak in sepsis: physiological basis and potential …
2024年3月23日 · Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of …
The glycocalyx as a permeability barrier: basic science and clinical ...
2022年9月12日 · Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown …
Three-dimensional ultrastructure of capillary endothelial …
2017年10月23日 · The sugar-protein glycocalyx coats all healthy vascular endothelium [1,2,3] and plays a key role in microvascular and endothelial physiology through its influence on the …
Association of sublingual microcirculation parameters and …
2019年7月24日 · Background The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states …
Fixing the leak: targeting the vascular endothelium in sepsis
2012年11月21日 · Angiopoietin-1 is a Tie-2 receptor agonist that stabilizes vascular endothelium, promoting endothelial maturation and preventing capillary leak. Angiopoietin-2 is largely a …
Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx ...
2019年3月9日 · Central to these new concepts is the endothelial glycocalyx, which lines the luminal aspect of the vascular endothelium. Knowledge of the endothelial glycocalyx has …
Markers of endothelial and epithelial pulmonary injury in …
2021年2月19日 · Background Biomarkers can be used to detect the presence of endothelial and/or alveolar epithelial injuries in case of ARDS. Angiopoietin-2 (Ang-2), soluble intercellular …
Bench-to-bedside review: Endothelial cell dysfunction in severe …
2003年1月6日 · During the past decade a unifying hypothesis has been developed to explain the vascular changes that occur in septic shock on the basis of the effect of inflammatory …
Targeting the host response in sepsis: current approaches and …
2023年12月6日 · Simultaneously, the activation of the complement system, the vascular endothelium, and the coagulation system results in microcirculatory disturbances. These …