2024年12月24日 · EHD2 (EH Domain Containing 2) is a Protein Coding gene. Diseases associated with EHD2 include Epilepsy, Idiopathic Generalized 2 and Distal Myopathy. Among its related pathways are Angiopoietin-like protein 8 regulatory pathway and Response to elevated platelet cytosolic Ca2+.

EH domain-containing protein 2 (EHD2) is a member of the EHD protein family and is mainly located in the plasma membrane, but can also be found in the cytoplasm and endosomes. EHD2 is also a nuclear-cytoplasmic shuttle protein.

2025年1月4日 · Data suggest that the EH-domain containing 2 protein (EHD2) NPF phenylalanine residue is crucial for EHD2 localization to the plasma membrane, whereas the proline residue is essential for EHD2 dimerization and binding.

2024年4月13日 · The overview and biological function of EH domain-containing protein 2 (EHD2) are discussed in this article. The article focuses on the role of EHD2 in metabolic diseases and cancer. The article also discussed the prospects for the future of EHD2 (Figure 1).

2017年11月13日 · Here, we used cellular assays with immunofluorescence, surface biotinylation, and patch clamping to demonstrate that Eps15 homology domain-containing protein 2 (EHD2) is a novel positive regulator of K ATP channel trafficking to increase surface K ATP channel density. EHD2 had no effect on cardiac Na + channels (Nav1.5).

2023年10月10日 · EHD2 Overexpression Suppresses the Proliferation, Migration, and Invasion in Human Colon Cancer. Effect of EH domain containing protein 2 on the biological behavior of clear cell renal cell carcinoma. EHD2 regulates adipocyte function and is enriched at cell surface-associated lipid droplets in primary human adipocytes.

Eps15 homology domain–containing 2 (EHD2) belongs to the EHD-containing protein family of dynamin-related ATPases involved in membrane remodeling in the endosomal system. EHD2 dimers oligomerize into rings on highly curved membranes, resulting in stimulation of the intrinsic ATPase activity.

Here, we used cellular assays with immunofluorescence, surface biotinylation, and patch clamping to demonstrate that Eps15 homology domain-containing protein 2 (EHD2) is a novel positive regulator of K ATP channel trafficking to increase surface K ATP channel density.

Although EHD2 is the first and only EHD protein whose complete structure has been solved , and despite evidence clearly implicating EHD2 in the regulation of endocytic transport, there is not yet a consensus on its precise function.

The EHD2 protein controls the association of membrane pits termed caveolae to cell surfaces. Caveolae are implicated in muscle, pulmonary, and lipid disorders. We establish functionally, and structurally, how EHD2 cycles between an active, ...