There are three typical treatment strategies: Most common: neoadjuvant chemotherapy plus HER2-targeted therapy. Most people with HER2+ breast cancer, including those with very small...

2024年7月24日 · The first HER2-targeted therapy, trastuzumab (Herceptin) combined with chemotherapy, improved overall survival outcomes of these cancers by 30% and reduced the risk of recurrence by 50%, says Mayo Clinic oncologist Ciara O’Sullivan, M.B., B.Ch.

Anti-HER2 therapies (also called HER2 inhibitors or HER2-targeted therapies) are a class of medicines used to treat all stages of HER2-positive breast cancer and certain HER2-low breast cancers.

2022年8月22日 · Treatment for HER2 positive breast cancer depends on the tumor’s size. Patients with tumors smaller than 2 centimeters, with no lymph nodes affected, will undergo surgery first, followed by chemotherapy and a single antibody targeting the HER2 protein known as trastuzumab (Herceptin).

2024年4月9日 · HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth of cancer cells. In about 1 of every 5 breast cancers, the cancer cells have extra copies of the gene that makes the HER2 protein.

2024年12月16日 · HER2-positive breast cancer, driven by an overproduction of HER2 proteins, has unique treatment options that improve outcomes. Treatments for early-stage HER2-positive cases often involve a combination of surgery (like lumpectomy or mastectomy), radiation, and HER2-targeted drugs, such as Herceptin and Perjeta.

HER2-positive (HER2+) breast cancer affects some people who have invasive breast cancer. This is a fast-growing cancer that can quickly spread from your breast to other areas of your body. Healthcare providers can treat and often cure this cancer if it’s caught early on.

HER2-targeted therapies are used to treat HER2-positive breast cancers. They have no role in the treatment of HER2-negative cancers. The HER2 status of a tumor is determined by testing tissue removed during a biopsy. All breast cancers are tested for HER2 status. About 10% to 20% of newly diagnosed breast cancers are HER2-positive [142-143].

2021年8月10日 · Several types of targeted therapy drugs can be used to treat breast cancer. In about 15% to 20% of breast cancers, the cancer cells make too much of a growth-promoting protein known as HER2. These cancers, known as HER2-positive breast cancers, tend to grow and spread more aggressively than HER2-negative breast cancers.

2024年10月24日 · HER2-directed therapy — Most patients with HER2-positive breast cancer will receive one or more chemotherapy drugs plus trastuzumab, the anti-HER2 antibody. Many studies have shown that these treatments dramatically improve survival for patients with HER2-positive breast cancer.