SETDB1 Gene - GeneCards | SETB1 Protein | SETB1 Antibody
2024年12月25日 · SETDB1 (SET Domain Bifurcated Histone Lysine Methyltransferase 1) is a Protein Coding gene. Diseases associated with SETDB1 include Huntington Disease and …
Structure, Activity and Function of the SETDB1 Protein ...
2021年8月11日 · The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent member of the Suppressor of Variegation 3-9 (SUV39)-related protein lysine …
Epigenetic silencing by SETDB1 suppresses tumour intrinsic ...
2021年5月5日 · SETDB1 loss derepresses latent TE-derived regulatory elements, immunostimulatory genes, and TE-encoded retroviral antigens in these regions, and triggers …
SETDB1: a perspective into immune cell function and cancer ...
SETDB1 immune functions include B cell maturation, T cell activity regulation, and immune escape in cancer cells. In B lymphocytes, SETDB1 mediates the transition from pro-B to pre-B …
SETDB1 SET domain bifurcated histone lysine methyltransferase 1 …
SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. …
Epigenetic silencing by SETDB1 suppresses tumour intrinsic ...
SETDB1 loss derepresses latent TE-derived regulatory elements, immunostimulatory genes, and TE-encoded retroviral antigens in these regions, and triggers TE-specific cytotoxic T cell …
SETDB1, an H3K9-specific methyltransferase: An attractive …
2024年5月1日 · SETDB1 is a crucial inhibitor of lung cancer at certain stages. SETDB1 coordinates with suppressor of mothers against decapentaplegic (SMAD)2/3 to form an …
SETDB1 in cancer: overexpression and its therapeutic implications
SETDB1 has five main functions: 1) Epigenetic Effects: SETDB1 is an epigenetic modifier involved mainly in H3K9 methylation. It can also contribute to H3K27 and DNA methylation. 2) …
Cell-type differential targeting of SETDB1 prevents aberrant CTCF ...
2024年1月2日 · SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9 trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The …
The functions of SET domain bifurcated histone lysine …
2023年12月7日 · In this review, we provide an overview of the complex biology of SETDB1, review the upstream regulatory mechanisms of SETDB1 and its partners, discuss the …
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