AMPK signaling to acetyl-CoA carboxylase is required for fasting …
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK …
AMPK-ACC signaling modulates platelet phospholipids and potentiates ...
2018年9月13日 · AMP-activated protein kinase (AMPK) α1 is activated in platelets on thrombin or collagen stimulation, and as a consequence, phosphorylates and inhibits acetyl-CoA …
AMPK: guardian of metabolism and mitochondrial homeostasis
2017年10月4日 · AMPK phosphorylation of acetyl-CoA carboxylases (ACCs) has been proposed as a master contributor to the changes in lipid synthesis that are induced by metformin, which …
AMPK-ACC signaling modulates platelet phospholipids and potentiates ...
2018年9月13日 · AMPK-ACC signaling in platelets is a key mechanism regulating primary hemostasis and arterial thrombosis. AMPK-ACC signaling controls collagen-induced TXA 2 …
AMP-activated protein kinase: the current landscape for drug ...
2019年3月13日 · Here, we assess the current state of play regarding the therapeutic potential of AMPK across distinct areas including metabolic diseases, cancer, neuromuscular disease, …
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces …
Acetyl-CoA carboxylase (ACC), a target for the energy-sensing AMP-activating protein kinase (AMPK), is the major controller of the rate of FAO within cells. Metformin has a well described …
New insights into activation and function of the AMPK
2022年10月31日 · Recent advances revealed several non-canonical pathways for AMPK activation, including roles of calcium, nutrients and metabolites, as well as DNA and lysosome …
AMPK signaling and its targeting in cancer progression and …
AMP-activated protein kinase (AMPK) serves as a central guardian maintaining energy homeostasis by orchestrating diverse cellular processes, such as lipogenesis, glycolysis, TCA …
AMPK: restoring metabolic homeostasis over space and time
AMPK can phosphorylate metabolic enzymes within the cytoplasm, such as acetyl-CoA carboxylase (ACC) 1 at ser79. This event inhibits energetically intensive lipid synthesis and …
Targeting AMPK for cancer prevention and treatment - PMC
2015年4月4日 · Acetyl-CoA carboxylase (ACC) is a well-established downstream target of AMPK involved in lipid metabolism . ACC catalyzes acetyl-CoA carboxylation to produce malonyl …
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