Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir. Type Small Molecule Groups

阿德福韦酯，是一种 有机化合物，化学式为C20H32N5O8P，是一种核苷类抗病毒药，被纳入国家医保乙类药物范畴。 用于治疗有乙型肝炎病毒活动复制证据，并伴有血清氨基酸转移酶（ALT或AST）持续升高或肝脏组织学活动性病变的肝功能代偿的成年慢性乙型肝炎患者。 [10] 根据中国国家药品不良反应监测数据库的分析，长期使用阿德福韦酯可能导致低磷血症和骨软化。 [11] 1991年，阿德福韦酯被美国Gilead公司发明。 [7] 1998年，专利EP 481214（1992）授权。 同族专 …

Gilson 等报道了adefovir dipivoxil 治疗慢性HBV感染的Ⅰ/Ⅱ临床研究结果。 研究采用双盲安慰剂对照的方法，有20例患者加入了研究，其中3例为HBV和HIV重叠感染，所有患者的HBsAg、HBeAg和HBV DNA均阳性，且ALT异常。

The main benefit of adefovir over lamivudine (the first NRTI approved for the treatment of HBV) is that it takes a much longer period of time for the virus to develop resistance to it. Adefovir dipivoxil contains two pivaloyloxymethyl units, making it a prodrug form of adefovir.

Find patient medical information for adefovir oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

2023年6月26日 · What Is Hepsera? Hepsera (adefovir dipivoxil) is an antiviral medication used to treat chronic hepatitis B in adults. What Are Side Effects of Hepsera? Hepsera may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, unusual muscle pain, trouble breathing, stomach pain, vomiting,

Adefovir dipivoxil (Hepsera) is an oral prodrug of the nucleotide analogue adefovir. It is indicated for the treatment of chronic hepatitis B in adults.

2024年9月23日 · Adefovir dipivoxil tablets are indicated for the treatment of chronic hepatitis B in patients 12 years of age and older with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Adefovir is the latest drug approved for therapy of chronic hepatitis B. This agent has a potent in vitro and in vivo effect against herpes virus, retroviruses and hepadnaviruses. In the hepatitis B virus setting, adefovir dipivoxil inhibits both the wild type and HBV lamivudine-resistant strains.

2016年2月15日 · Adefovir dipivoxil is an acyclic nucleotide analogue of adenosine used either alone or in combination with other agents as therapy of chronic hepatitis B. Adefovir does not appear to be a significant cause of drug induced liver injury, but initiation of therapy and sudden withdrawal of therapy can induce a transient exacerbation of the ...