Alefacept - Wikipedia
Alefacept is a genetically engineered immunosuppressive drug. It was sold under the brand name Amevive in Canada, the United States, Israel, Switzerland and Australia. In 2011, the manufacturers made a decision to cease promotion, manufacturing, distribution and sales of Amevive during a supply disruption.
Alefacept: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · A medication used to treat psoriasis, a skin condition causing scaly or itchy patches on the skin. Alefacept is a recombinant fusion protein that binds CD2 and is used treat moderate to severe plaque psoriasis.
Alefacept (intramuscular route) - Mayo Clinic
2006年10月28日 · Alefacept is an immunosuppressant. It works on the immune system to treat the symptoms of plaque psoriasis. This medicine is to be given only by or under the direct supervision of a doctor.
Amevive (Alefacept): Side Effects, Uses, Dosage, Interactions ... - RxList
2023年5月3日 · Amevive (alefacept) is a protein that works by affecting the body's immune system to decrease plaques/dead skin cells used for the treatment of moderate to severe chronic plaque psoriasis in people who are candidates for systemic therapy or phototherapy.
AMEVIVE® (alefacept) is an immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1.
Amevive: Uses, Dosage, Side Effects, Warnings - Drugs.com
2024年8月23日 · Amevive is used to treat plaque psoriasis (raised, silvery flaking of the skin) in adults. Amevive may also be used for purposes not listed in this medication guide. You should not use Amevive if you are allergic to alefacept, or if you have HIV (human immunodeficiency virus).
The safety and efficacy of alefacept in the treatment of chronic …
Alefacept is the first biological agent approved by the US Food and Drug Administration (FDA) for the treatment of moderate to severe chronic plaque psoriasis. It is a full human fusion protein binding to CD2 on T cells.
Alefacept - LiverTox - NCBI Bookshelf - National Center for ...
2021年9月15日 · Alefacept is a recombinant fusion protein of lymphocyte function associated antigen-3 (LFA-3) and immunoglobulin G dimer that acts to block the activation of T cells, and is an immunosuppressive agent that was previously …
Alefacept: where it stands today - PubMed
Alefacept is one of the first biologics in the treatment of psoriasis. It selectively reduces CD45RO(+) memory T cells and inhibits T-cell activation. Clinical data support its safety and efficacy in a substantial subset of patients with psoriasis.
alefacept (Amevive): Psoriasis Drug Side Effects & Dosage - MedicineNet
Alefacept (Amevive) is a drug prescribed to treat adult patients with with moderate to severe chronic plaque psoriasis. Side effects, drug interactions, warnings and precautions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.