Pharmaceutical amorphous solid dispersion: A review of …
2021年8月1日 · Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging.
Amorphous solid dispersions: An update for preparation ...
Amorphous solid dispersion (ASD) provides a scope to improve the bioavailability and therapeutic efficiency by enhancing the physicochemical properties like solubility of poorly aqueous soluble drugs.
Amorphous solid dispersions: Stability mechanism, design …
2023年11月5日 · This review provides a comprehensive SD classification and identifies the most popular amorphous solid dispersions (ASDs). Meanwhile, this review further puts forward the systematic design strategy of satisfactory ASDs in terms of drug properties, carrier selection, preparation methods and stabilization mechanisms.
Manufacturing strategies to develop amorphous solid dispersions…
In the present review, we attempt to discuss the important and industrially scalable thermal strategies for the development of amorphous SD. These include both solvent (spray drying and fluid bed processing) and fusion (hot melt extrusion and KinetiSol®) based techniques.
Amorphous Solid Dispersions: Theory and Practice - Springer
This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs.
Advances in the development of amorphous solid dispersions: …
2023年7月1日 · Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level.
Amorphous solid dispersions: An update for preparation
2020年8月30日 · Amorphous solid dispersions (ASDs) are being employed frequently to improve bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in drug product development process.
Amorphous solid dispersions of enzalutamide and novel
2020年10月28日 · Amorphous solid dispersion (ASD) is a widely employed formulation technique for drugs with poor aqueous solubility. Polymers are integral components of ASDs, but mechanisms by which polymers lead...
Amorphous Solid Dispersions (ASDs): The Influence of Material
2021年10月14日 · Recent advances in the analytical tools to characterize ASDs stability and ability to be processed into suitable, patient-centric dosage forms are also described.
Amorphous solid dispersion to facilitate the delivery of poorly …
Introduction: Amorphous solid dispersion (ASD) technique has recently been used as an effective formulation strategy to significantly improve the bioavailability of insoluble drugs.
Pharmaceutical amorphous solid dispersion: A review of …
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging.
Recent Advances in Amorphous Solid Dispersions: …
2022年10月16日 · Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress.
Amorphous Solid Dispersions: Role of the Polymer and Its …
Amorphous solid dispersions stabilized by one or more polymer(s) have been widely used for delivering amorphous drugs with poor water solubilities, and they have gained great market success. Polymer selection is important for preparing robust ...
Formulating Drug Products through Use of Amorphous Solid Dispersions
2022年8月30日 · CDER scientists are seeking ways to improve the bioavailability of drugs that on their own do not dissolve well in water. Recent CDER research explores the potential for using amorphous solid...
Amorphous Solid Dispersion - an overview | ScienceDirect Topics
Amorphous solid dispersions are designed to preserve the active pharmaceutical ingredients in their amorphous form by dispersing the drug substance within an inactive polymeric carrier system.
Molecular Insights on Kinetic Stabilization of Amorphous Solid ...
2 天之前 · Amorphous solid dispersions with biocompatible polymer excipients offers a solution to overcome this problem, potentially enabling a broader use of many drug candidate molecules. This work addresses various aspects of in silico design of a suitable combination of an API and a polymer to form such a binary solid dispersion. Molecular ...
Recent Advances in Amorphous Solid Dispersions: …
Amorphous solid dispersions (ASDs) are among the most popular and widely studied solubility enhancement techniques. Since their inception in the early 1960s, the formulation development of ASDs has undergone tremendous progress.
Amorphous Solid Dispersions: Role of the Polymer and Its
2022年8月22日 · This article provides a comprehensive overview for recent developments in the understanding the role of polymers in amorphous solid dispersions from the aspects of nucleation, crystal growth, overall crystallization, miscibility, phase separation, dissolution, and supersaturation.
Dissolution Mechanisms of Amorphous Solid Dispersions: A …
Despite the recent success of amorphous solid dispersions (ASDs) at enabling the delivery of poorly soluble small molecule drugs, ASD-based dosage forms are limited by low drug loading. This is partially due to a sharp decline in drug release from the ASD at drug loadings surpassing the ‘limit of congruency’ (LoC).
Amorphous Solid Dispersions (ASDs): The Influence of Material ...
Amorphous solid dispersion characterization requires numerous orthogonal techniques in order to investigate drug–polymer interactions that influence various parameters such as drug–polymer affinity and miscibility, glass transition temperature of the ASD, molecular mobility and detection of potential crystallization.
Trends in amorphous solid dispersion drug products approved …
Forty-eight (48) drug products (DPs) containing amorphous solid dispersions (ASDs) have been approved by the U.S. Food and Drug Administration in the 12-year period between 2012 and 2023. These DPs comprise 36 unique amorphous drugs. Ten (10) ...
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