Arketamine - Wikipedia
Arketamine (developmental code names PCN-101, HR-071603), also known as (R)-ketamine or (R)-(−)-ketamine, is the (R)-(−) enantiomer of ketamine.
Ketamine, Esketamine, and Arketamine: Their Mechanisms of …
Arketamine, with fewer side effects and possibly more potent antidepressant effects than esketamine, shows promise but requires further research to verify its long-term safety and effectiveness. While esketamine is already in clinical use, arketamine’s future depends on additional trials to resolve outstanding concerns about its safety ...
Arketamine, a new rapid-acting antidepressant: A historical …
2022年11月1日 · A phase 2 clinical trial of arketamine in treatment-resistant patients with MDD is underway. This study was designed to review the brief history of the novel antidepressant arketamine, the molecular mechanisms underlying its …
Arketamine: a scoping review of its use in humans
5 天之前 · Arketamine (R-ketamine), an enantiomer of ketamine, has historically been less studied than esketamine (S-ketamine) and the racemic mixture. Recent preclinical studies suggest that arketamine may offer prolonged antidepressant effects and a superior safety profile. This scoping review aims to assess and synthesise existing literature on the clinical use of arketamine in …
Arketamine, a new rapid-acting antidepressant: A historical …
2022年11月1日 · Taken together, arketamine would be a novel rapid-acting antidepressant without the side effects of (R,S)-ketamine and esketamine. This study aimed to review the brief history of arketamine, the molecular mechanisms underlying its …
Ketamine, Esketamine, and Arketamine: Their Mechanisms of
2024年10月9日 · Approved by the FDA and EMA in 2019, esketamine is currently used alongside SSRIs or SNRIs for treatment-resistant depression (TRD). On the other hand, arketamine has shown potential for treating neurological disorders such as Alzheimer's, Parkinson's, and multiple sclerosis, offering possible antidepressant effects and anti-inflammatory benefits.
Molecular mechanisms underlying the antidepressant actions …
2021年5月7日 · In this paper, we review recent findings on the molecular mechanisms underlying the antidepressant actions of (R,S)-ketamine and its potent enantiomer arketamine.
Arketamine: a scoping review of its use in humans - PubMed
Arketamine (R-ketamine), an enantiomer of ketamine, has historically been less studied than esketamine (S-ketamine) and the racemic mixture. Recent preclinical studies suggest that arketamine may offer prolonged antidepressant effects and a superior safety profile. This scoping review aims to assess …
Ketamine, Esketamine, and Arketamine: Their Mechanisms of …
2024年10月9日 · Esketamine has been found to be more potent, offering three times stronger analgesic effects and 1.5 times greater anesthetic efficacy than arketamine. It provides smoother anesthesia with fewer...
Ketamine: A tale of two enantiomers - PMC
Ketamine is a racemic mixture that consists of equal amounts of two enantiomers, (S)-ketamine and (R)-ketamine (or esketamine and arketamine) (Figure 1). (S)-ketamine has a three to fourfold greater binding affinity for the NMDA receptor than (R)-ketamine (Ki = 0.30 μM and Ki = 1.4 μM respectively) (Ebert et al., 1997).