2024年10月9日 · This review centers on methodologies and syntheses in organic reactions involving multiple arynes, categorizing based on mechanisms like cycloadditions, σ-bond insertions, nucleophilic additions, and ene reactions, and discusses aryne polymerization.

An aryne, also known as a benzyne, is a highly reactive intermediate species in organic chemistry that consists of a benzene ring with a triple-bonded carbon-carbon unit. Arynes are important in many organic reactions and are often used as reactive intermediates in …

Arynes are an interesting class of reactive intermediates which can be used as versatile building blocks in organic chemistry, as convincingly documented by their application in natural product synthesis. [1] .

2024年4月30日 · Here, we showcase our effort to manipulate chemoselective control between two major types of aryne transformations using either 3-methoxybenzyne or 3-silylbenzyne, where nucleophilic...

2015年7月13日 · Here, we demonstrate the generation and characterization of individual polycyclic aryne molecules on an ultrathin insulating film by means of low-temperature scanning tunnelling microscopy and...

2023年2月2日 · Here, we describe a two-step formal dehydrogenation of simple arenes to generate arynes at a remote position relative to traditionally reactive groups, e.g., halides.

2023年3月31日 · This Review focuses on one of the most challenging issues in aryne chemistry, catalytic asymmetric reactions using aryne intermediates, and presents the recent advances in this field.

2021年2月18日 · Nowadays, o-silylaryl triflates are the most frequently employed aryne precursors. This review provides an overview of the history of Kobayashi’s method, its methodological achievements, and its applications in the synthesis of natural products, bioactive molecules, and polycyclic aromatic hydrocarbons.

Comprehensive Aryne Synthetic Chemistry summarizes the progress in the synthetic utilization of arynes for noncatalytic and transition metal-catalyzed reactions developed in the last 20 years.

Initial speculation on the existence of aryne intermediate appeared in 1902. Stoermer and Kahlert provided the first evidence for the existence of arynes when they observed the formation 2-ethoxybenzofuran in the reaction of