The basic immunology of asthma - PubMed
2021年3月18日 · Here, we review the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.
The immunology of asthma - Nature Immunology
2014年12月18日 · Asthma is a chronic inflammatory disease of the conducting airways in which many cells of the innate and adaptive immune systems act together with epithelial cells to cause bronchial hyper ...
AAAAI | American Academy of Allergy, Asthma & Immunology
The American Academy of Allergy, Asthma & Immunology (AAAAI) is the leading membership organization of more than 7,100 allergists / immunologists and patients' trusted resource for allergies, asthma and immune deficiency disorders.
The immunology of asthma - PubMed
Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (TH2) disease of the airways.
Immunologic mechanisms in asthma - PubMed
Asthma is associated with immune system activation, airway hyperresponsiveness (AHR), epithelial cell activation, mucus overproduction and airway remodeling. Both innate and adaptive immunity play roles in immunologic mechanisms of asthma. Type 2 asthma with eosinophilia is a common phenotype in asthma. It occurs with and without visible allergy.
The basic immunology of asthma - Cell Press
2021年3月11日 · Hammad and Lambrecht review the immunological basis of asthma endotypes by discussing results from animal studies that have unraveled molecular pathways and clinical studies targeting specific immune pathways using molecule-specific biologics.
Understanding Asthma Phenotypes, Endotypes, and Mechanisms …
The precise definition of these endotypes is central to asthma management due to inherent therapeutic and prognostic implications. This review presents the molecular mechanisms behind the heterogeneity of airway inflammation in asthmatic patients. Asthma endotypes may be broadly regarded as type 2 (T2) high or T2-low.
The basic immunology of asthma - ScienceDirect
2021年3月18日 · Asthma symptoms are driven by the inflammation of the airways, which triggers processes such as mucus production, remodeling of the airway wall, and bronchial hyperresponsiveness (BHR, which is the tendency of smooth muscle cells to react to non-specific stimuli such as cold air.
Frontiers | Immunologic aspects of asthma: from molecular …
2024年10月7日 · The clinical traits of asthma, i.e., dyspnea, coughing, wheezing, chest tightness, loss of lung function, exacerbation tendency, and asthma severity, suggest that the disease encompasses distinct underlying mechanisms, in which structural and immune cells interact to manifest the pathogenetic features of asthma.
The Immunology of Asthma: Asthma Phenotypes and Their …
If asthma were just a disease of the adaptive immune system, then everyone with allergic rhinitis would have asthma. By definition, all AR patients have a full repertoire of differentiated allergen-specific Th2 lymphocytes and have demonstrated their production of IgE by allergen-specific B …