2019年6月17日 · It has been fairly well documented that grapefruit juice can interact with several drugs, including Lipitor (atorvastatin), a 'statin' medication used to lower cholesterol. However, how much grapefruit juice one needs to consume to produce a clinically significant drug interaction isn't entirely known.

2018年1月25日 · Citrus seed extract, also known as grapefruit seed extract, has been shown to inhibit CYP3A4 which is important in breaking down atorvastatin. This can lead to the same adverse effects that are worrisome with grapefruit—muscle pain and …

2024年3月6日 · Grapefruit may interact with atorvastatin and cause side effects. Avoid consuming grapefruit products and drinking more than 1.2 liters of grapefruit juice each day. What other drugs will affect atorvastatin? Sometimes it is not safe to use certain medicines at the same time.

2024年3月10日 · Grapefruit juice can even interact with some over-the-counter (OTC) drugs. Examples of common medications that may interact with grapefruit juice include: Certain statin drugs used to lower cholesterol such as atorvastatin , lovastatin, simvastatin . Loratadine (Claritin Allergy), a common OTC non-sedating antihistamine.

2024年1月3日 · Atorvastatin works by blocking an enzyme, called HMG-CoA reductase, in the liver that makes different types of lipids (this is the collective term for fats and cholesterol). Atorvastatin also boosts the breakdown of lipids. Atorvastatin belongs to the class of medicines known as statins. Atorvastatin is also known as an HMG-CoA reductase ...

2025年1月9日 · Several compounds within grapefruit can block the CYP3A enzyme from being able to metabolize atorvastatin. Therefore, when atorvastatin is ingested at the same time as grapefruit juice, the body is unable to properly metabolize the medication, causing an increase in the blood serum concentration of atorvastatin by about 80 percent, regardless ...

2025年1月23日 · Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking atorvastatin calcium [see Drug Interactions ]. Discontinue atorvastatin calcium tablets if markedly elevated CK levels occur or if myopathy is either diagnosed or suspected.

2017年9月28日 · In terms of Lipitor, there can be a slight interaction here. The general recommendation is that grapefruit juice should be avoided in patients taking atorvastatin to avoid the potential for drug accumulation and toxicity. This toxicity may manifest itself in the following adverse reactions: muscle pain and weakness, headache and GI complaints.

2023年10月12日 · Avoid consuming grapefruit products and drinking more than 1.2 liters of grapefruit juice each day. Lipitor side effects Get emergency medical help if you have signs of an allergic reaction to Lipitor (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat , burning eyes, skin pain, red or ...

2024年12月2日 · Out of all the statins, atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Altoprev) have the strongest interaction with grapefruit, and this is likely to be true for other citrus. Grapefruit juice and any grapefruit products should be avoided, as should large quantities of limes or lime peel, although small amounts (such as a twist ...