Aztreonam. A review of its antibacterial activity ... - PubMed
Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams. Aztreonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria.
Aztreonam - Wikipedia
Spectrum of activity [ edit ] Acinetobacter anitratus , Escherichia coli , Pseudomonas aeruginosa , and Proteus mirabilis are generally susceptible to aztreonam, while some staphylococci , Staphylococcus aureus , Staphylococcus haemolyticus …
Aztreonam: Uses, Interactions, Mechanism of Action - DrugBank …
Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa.
Aztreonam - Antimicrobe
Aztreonam produces time-dependent killing. Pharmacokinetics. Cmax: 255mg/L (after 2g IV dose); Half-life: 1.7 to 2 hours; Protein binding: 56 to 72%; Volume of distribution: 0.06 L/kg . Adverse Effects. Dermatologic: rash (rare)
Such directed therapy is provided by aztre- onam. Its narrow spectrum can, if necessary, be broadened by com- tendant side effects such as disturbances of the natural gut flora, diarrhea, and the emergence of resistant bacteria.
aztreonam, although aztreonam is active in vitro against most aminoglycoside-resistant strains of En- terobacter, Klebsiella, and Serratia. Aztreonam inhibits all Neisseria meningitidis and Neisseria gonorrhoeae at 0.03 to 0.06 pg/ml, including penicillinase-producing N. …
review of the pharmacokinetics and pharmacodynamics of aztreonam …
2016年6月21日 · In vitro data confirm that aztreonam in combination with cefepime or ceftazidime 61 and in combination with ceftazidime and amikacin 62 has bactericidal activity against certain P. aeruginosa strains, which is not achieved by monotherapy.
Aztreonam | C13H17N5O8S2 | CID 5742832 - PubChem
Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa.
Aztreonam | Drugs - Springer
2012年10月18日 · In vivo, the activity of aztreonam has been demonstrated in a variety of experimental Gram-negative bacterial infections in animals and was similar to that of cefotaxime and ceftazidime against pseudomonal infections and H. influenzae meningitis.
Aztreonam activity, pharmacology, and clinical uses - PubMed
1990年3月23日 · Administered parenterally, aztreonam provides peak serum concentrations for most Enterobacteriaceae and Pseudomonas aeruginosa. It is widely distributed throughout the body. Excretion is largely dependent on renal mechanisms, so dosage can be adjusted in the presence of renal impairment.