2024年12月24日 · BNIP3 (BCL2 Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include Leiomyomatosis and Pancreatic Cancer. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Photodynamic therapy-induced HIF-1 survival signaling.

2009年2月20日 · BNIP3 (BCL2 and adenovirus E1B 19-kDa-interacting protein 3) and BNIP3-like (BNIP3L), also known as NIX, are proteins with homology to BCL2 in the BH3 domain, which induce both cell death and...

2022年4月11日 · Autophagy-mediated mitochondrial degradation plays pivotal roles in both the acquisition and maintenance of pluripotency, but the molecular mechanisms that link autophagy-mediated mitochondrial...

BNIP3 knockdown altered mitochondrial morphology, and number, and increased mitophagy. Interestingly, BNIP3 deficiency in NP cells reduced glycolytic capacity reflected by lower production of lactate/H + and lower ATP production rate.

Bcl-2 nineteen kilodalton interacting protein (BNIP3) is a BH-3 only Bcl-2 family member that its expression levels increase during stress such as hypoxia through hypoxia inducing factor -1 (HIF-1) dependent or independent mechanisms.

2021年12月20日 · BNIP3L promotes mitophagy either via recruiting autophagosomes to target mitochondria or enhancing the formation of autophagosomes. BNIP3L-mediated mitophagy is regulated at the...

The Bcl-2 adenovirus E1B 19 kDa-interacting protein 3 (Bnip3) is a pro-apoptotic BH3-only protein associated with the pathogenesis of many diseases, including cancer and cardiovascular disease. Studies over the past decade have provided insight into ...

2024年11月27日 · BNIP3 deletion can be used as a prognostic marker of tumor progression to metastasis in human triple-negative breast cancer; BNIP3 expression was found to be regulated by Sp3 in prostate cancer.

Recent studies have discovered that Bnip3 regulates mitochondrial dysfunction, mitochondrial fragmentation, mitophagy, cell apoptosis, and the development of lipid disorder diseases via numerous cellular signaling pathways.

2024年12月10日 · Title: Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome. BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.