The basal ganglia in Parkinson's disease: current concepts and
The pathophysiology of Parkinson's disease is reviewed in light of recent advances in the understanding of the functional organization of the basal ganglia (BG).
Basal Ganglia and Parkinson’s Disease: How are they Connected?
2021年6月25日 · The Basal Ganglia refers to a group of structures located beneath the cortex of the brain called “subcortical nuclei”. With Parkinson’s Disease, there is dysfunction within the basal ganglia. In this blog post, we will discuss the anatomy of the basal ganglia and the pathophysiology of Parkinson’s Disease.
Basal ganglia circuits changes in Parkinson’s disease patients
Functional changes in basal ganglia circuitry are responsible for the major clinical features of Parkinson’s disease (PD). Current models of basal ganglia circuitry can only partially explain the cardinal symptoms in PD.
Push-pull effects of basal ganglia network in Parkinson’s disease ...
2024年11月20日 · Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson’s disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data...
Functional changes of the basal ganglia circuitry in Parkinson's disease
In Parkinson's disease, the degeneration of dopaminergic neurons of the substantia nigra pars compacta triggers a cascade of functional changes affecting the whole basal ganglia network. The most relevant alterations affect the output nuclei of the circuit, the medial globus pallidus and substantia nigra pars reticulata, which become hyperactive.
Biology of Parkinson's disease: pathogenesis and pathophysiology of …
Parkinson's disease (PD), which afflicts nearly 1 % of the population above the age of 60, is a multisystem neurodegenerative disorder in which progressive loss of midbrain dopamine (DA) neurons, with resulting dopaminergic deafferentation of the basal ganglia, gives rise to characteristic motor disturbances that include slowing of movement ...
The basal ganglia in Parkinson's disease: Current concepts and ...
The pathophysiology of Parkinson's disease is reviewed in light of recent advances in the understanding of the functional organization of the basal ganglia (BG).
Illuminating Basal Ganglia and Beyond in Parkinson’s Disease
In this issue of Movement Disorders, 4 articles have used magnetic resonance imaging to uncover new insights into the structural deficits in Parkinson’s disease in a key region of importance, namely, the substantia nigra (SN). Three types of biomarkers were investigated that can investigate iron load, neuromelanin content, and microstructural ...
Pathophysiology of the basal ganglia in Parkinson's disease
Insight into the organization of the basal ganglia in the normal, parkinsonian and L-dopa-induced dyskinesia states is critical for the development of newer and more effective therapies for Parkinson's disease.
Basal Ganglia Circuits as Targets for Neuromodulation in Parkinson Disease
Efforts are under way to target circuit dysfunction in brain areas outside of the traditionally implicated basal ganglia thalamocortical system, in particular, the pedunculopontine nucleus, to address gait disorders that respond poorly to levodopa and conventional DBS targets.