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    Basement membrane - Wikipedia

    • As seen with the electron microscope, the basement membrane is composed of two layers, the basal lamina and the reticular lamina. The underlying connective tissue attaches to the basal lamina with collagen VII anchoring fibrils and fibrillin microfibrils. The basal lamina layer can further be subdivided into two layers based on their visual appearance in electron mi… 展开

    Overview

    The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of 展开

    Function

    The primary function of the basement membrane is to anchor down the epithelium to its loose connective tissue (the dermis or lamina propria) underneath. This is achieved by cell-matrix adhesions through substrate adhesi… 展开

    Clinical significance

    Some diseases result from a poorly functioning basement membrane. The cause can be genetic defects, injuries by the body's own immune system, or other mechanisms. Diseases involving basement membranes at m… 展开

    Evolutionary origin

    These are only found within diploblastic and homoscleromorphic sponge animals. The homoscleromorph were found to be sister to diploblasts in some studies, making the membrane originate once in the history of life. But more rec… 展开

    See also

    Tunica intima – Inner layer of blood vessel 展开