The Mechanism of Enterohepatic Circulation in the Formation of ...
Bile acids entering into enterohepatic circulating are primary acids synthesized from cholesterol in hepatocyte. They are secreted actively across canalicular membrane and carried in bile to …
Bile Acid Metabolism and Signaling - PMC - PubMed Central (PMC)
Enterohepatic circulation of bile acids is highly efficient in humans and is an important physiological system not only for nutrient absorption and xenobiotic disposal, but also for …
Bile acid metabolism and signaling in health and disease: …
2024年4月26日 · Bile acid metabolism and signaling pathways play a crucial role in protecting against, or if aberrant, inducing cardiometabolic, inflammatory, and neoplastic conditions, …
Physiology, Bile Secretion - StatPearls - NCBI Bookshelf
2022年9月26日 · The main steps in the formation of bile are the uptake of bile acids and ions from plasma across the basolateral (sinusoidal) membrane, transport through the hepatocyte, and …
Bile Acids and Metabolic Regulation - PubMed Central (PMC)
Upon ingestion of a meal, gallbladder contraction releases micellar bile acids into the intestinal lumen to aid digestion. Enterohepatic circulation enables 95% of bile acids to be reabsorbed …
Physiology, Bile Acids - StatPearls - NCBI Bookshelf
2023年5月1日 · Bile acids get conjugated in the liver to increase their water solubility because bile salts have a decreased pK, which favors the basic anionic form in the acidic duodenum. As …
Bile Acid Synthesis, Metabolism, and Biological Functions
2024年10月7日 · Conjugation of bile acids involves the sequential action of bile acid-CoA synthetase (BACS) and bile acid-CoA:amino acid N-acetyltransferase (encoded by the BAAT …
Role of bile acids and their receptors in gastrointestinal and …
2022年2月14日 · Bile acid (BA)-activated nuclear receptors maintain BA homeostasis by regulating BA metabolism and transport within the enterohepatic circulation.
The changing metabolic landscape of bile acids - Nature
2024年4月4日 · Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community composition and mediate inflammation, and they serve …
Enterohepatic circulation of bile acids and their emerging roles …
2021年1月1日 · Enterohepatic circulation of bile acids links the hepatic and intestinal metabolism. Bile acids play a significant role in glucolipid metabolism via FXR and TGR5. Bile acids (BAs) …
Bile Acid Signaling Pathways from the Enterohepatic Circulation …
2017年11月6日 · Once in the systemic circulation, bile acids reach the brain via the internal carotid and vertebral arteries that join in an artery ring at the base of the brain—the circle of …
Bile Acid Metabolism in Liver Pathobiology - PMC - PubMed …
The gut-to-liver axis plays a critical role in the regulation of enterohepatic circulation of bile acids, bile acid pool size, and bile acid composition. Bile acids control gut bacteria overgrowth, and …
Bile acid signaling in the regulation of whole body metabolic and ...
Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are …
Bile acid metabolism and signalling in liver disease
2024年9月28日 · Enterohepatic circulation of bile acids. In the liver, FXR inhibits CYP7A1 in a SHP-dependent manner. FXR induces canalicular BSEP, which actively secretes conjugated …
Bile acid metabolism and signaling - PubMed
Enterohepatic circulation of bile acids from the liver to intestine and back to the liver plays a central role in nutrient absorption and distribution, and metabolic regulation and homeostasis. …
Metabolic Messengers: bile acids | Nature Metabolism
2022年3月25日 · Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as …
Bile acid metabolism and signaling in cholestasis, inflammation …
Bile acids are physiological detergent molecules, so are highly cytotoxic. They undergo enterohepatic circulation and play important roles in generating bile flow and facilitating biliary …
Bile acids regulation of cellular stress responses in liver physiology ...
2024年5月30日 · Recent research has discovered new links of bile acid signalling to the regulation of autophagy and lysosome biology, redox homeostasis and endoplasmic reticulum …
Ileal microbial microbiome and its secondary bile acids modulate ...
2024年11月23日 · The gut‒liver axis, particularly the enterohepatic circulation of bile acids (BAs), plays a crucial role in regulating the liver diseases. Since the ileum is the primary site for BAs …
Bile acids: regulation of synthesis - PMC - PubMed Central (PMC)
The enterohepatic circulation of bile acids exerts important physiological functions not only in feedback inhibition of bile acid synthesis but also in control of whole-body lipid homeostasis.
Bile acids and the gut microbiota: metabolic interactions and …
2022年10月17日 · In this Review, we highlight how the bile acid pool is manipulated by the gut microbiota, how it is dependent on the metabolic capacity of the bacterial community and how …
Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic ...
Bile acids are synthesized from cholesterol in the liver, excreted with bile into the duodenum, almost completely taken up again in the distal ileum and finally returned to the liver with portal …
The acidic microenvironment in the perisinusoidal space critically ...
3 天之前 · Upon passive entry of a protonated bile acid into the cell, the acid would be deprotonated to the corresponding bile salt due to the more alkaline pH present in the …