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2024年9月5日 · Recreating a biomimetic and functional cornea requires adherence to specific criteria, including essential properties such as biocompatibility, biodegradability, transparency, and mechanical properties that mimic the microstructure of the host tissue while maintaining a curved morphology (Mahdavi et al., 2020b). The goal is not an exact ...

The cornea is the outermost layer of the eye and serves to protect the eye and enable vision by refracting light. The need for cornea organ donors remains high, and the demand for an artificial alternative continues to grow. 3D bioprinting is a ...

2024年12月18日 · Herein, we propose the “biomimetic EBM” strategy as a potential solution for corneal scarring (Fig. 1), with bioactive Hep@Gel bioengineered from methacrylated gelatin (GelMA) and thiolated heparin (HepSH), which could robustly modulate the microenvironment without additional cells or drugs.

2018年8月1日 · British tissue engineers have demonstrated that a 3-D printer, using bioink made from collagen, alginate, and keratocytes, can fabricate tissue that has the shape and structure of the native human corneal stroma.

2023年1月23日 · Biosynthetic cornea model using 3D printing technique is promising to generate artificial corneal structure that can resemble the structure of the native human cornea and is applicable for regenerative medicine.

2023年9月15日 · The cornea is the outermost layer of the eye and serves to protect the eye and enable vision by refracting light. The need for cornea organ donors remains high, and the demand for an artificial alternative continues to grow. 3D bioprinting is a promising new method to create artificial organs and ti …

2019年9月1日 · 3D bioprinting can be a promising approach for corneal substitution. The advantages of this technology in corneal regeneration enable personalized corneal implant and single or multi-layer corneal equivalents with controllable structure and designed refractive ability.

2024年11月1日 · Bioengineered cornea has demonstrated innervation in both in vivo and in vitro environments, with correlating return of touch sensitivity in vivo models. Despite the progress and potential, numerous challenges remain to be addressed, including achieving innervation density that mimics the complex corneal nerve architecture and ensuring long ...

2020年7月6日 · In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab.