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小细胞肺癌肿瘤组织及血清CD44表达及临床预后意义 - PMC
Suda等 发现CD44可能通过上皮间质转化诱导NSCLC靶向治疗耐药,Zhang等 研究证实肺腺癌患者肿瘤组织CD44与PD-L1表达正相关,CD44高表达可提示患者预后不良,Nguyen等 则认为 …
靶向肿瘤干细胞的药物开发靶点:CD44 - 知乎 - 知乎专栏
cd44是一种复杂的跨膜粘附糖蛋白,表达于人的多种细胞,包括 胚胎干细胞 、分化细胞和癌细胞。转录过程中不同的选择性剪接,产生cd44的两种亚型,包括标准亚型(cd44s)和cd44变异亚 …
CD44 - 百度百科
已在人类各种 恶性肿瘤 的研究中发现cd44s普遍存在,cd44v在恶性肿瘤组织中阳性表达率高低不一但阳性表达者较易发生 脉管 浸润和远处转移,阳性表达者无瘤生存期短, 生存率 低, 预 …
The biology and role of CD44 in cancer progression: therapeutic ...
Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the potential for targeting …
Single-cell transcriptomics identifies CD44 as a marker and ... - Nature
2020年1月29日 · Using single-cell transcriptome analysis and antibody screening, we identify CD44 as a marker of EHT enabling us to isolate robustly the different stages of EHT in the …
CD44: can a cancer-initiating cell profit from an abundantly
2011年3月10日 · In human breast cancer cells, EMT corresponds to the CD44 + /CD24 − CIC type 62, in which the EMT phenotype is associated with strong CD44 upregulation and CD44 …
CD44: A Multifunctional Mediator of Cancer Progression - PMC
CD44 mediates invasion and metastasis by binding to HER2, leading to the inhibition of miR-139 and upregulation of CXCR4. There is positive crosstalk between CD44 and FGFR2 to maintain …
CD44 - 维基百科,自由的百科全书 - zh.wikipedia.org
2021年10月17日 · cd44,在人体内是一种由11号染色体上的cd44基因编码的细胞表面黏附分子,化学本质是糖蛋白,属于一类分化簇(cd) [5] [6] 。cd44是一种常用的干细胞表面标记 …
选择素、cd44 透明质酸相互作用介导的细胞粘附动力学在经典炎症反应、肿瘤转移或组织特异的肝脏免疫中 具有重要作用. 该综述分别从细胞层次粘附动力学、二维与三维条件下的分子层次反 …
CD44 as a tumor biomarker and therapeutic target
2020年12月10日 · In this review, we focus on current data relevant to CD44, and outline CD44 structure, the regulation of CD44, functional properties of CD44 in carcinogenesis and cancer …