COSMIC | Catalogue of Somatic Mutations in Cancer
COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Start using COSMIC by searching for a gene, cancer type, mutation, etc. below.
Genetic Mutations | Types of Mutations - American Cancer Society
To learn about some of the more common inherited gene mutations that can lead to cancer, see Family Cancer Syndromes. An acquired gene mutation is not inherited from a parent. Instead, it develops at some point during a person's life. Acquired mutations occur in one cell, and then are passed on to any new cells that come from that cell.
The Genetics of Cancer - NCI - National Cancer Institute
Scientists have found hundreds of DNA and genetic changes (also called variants, mutations, or alterations) that help cancer form, grow, and spread. Cancer-related genetic changes can occur because: DNA changes, whether caused by a random mistake or by a carcinogen, can happen throughout our lives and even in the womb.
Mutational landscape of cancer-driver genes across human …
2023年8月7日 · In this study, we investigate the genomic sequences of 20,331 primary tumours representing 41 distinct human cancer types to identify and catalogue the driver mutations present in 727 known...
A compendium of mutational cancer driver genes - Nature
2020年8月10日 · In this Review, we present the Integrative OncoGenomics (IntOGen) pipeline, an implementation of such an approach to obtain the compendium of mutational cancer drivers. Its application to somatic...
How Genetic Changes Lead to Cancer - NCI - National Cancer …
Some types of genetic mutations change proteins in ways that cause healthy cells to become cancerous. Genetic mutations can change how proteins and cells function. This infographic outlines how proteins are made from genes and explains certain types of genetic mutations that are found in cancer.
Mutational landscape and significance across 12 major cancer types
2013年10月16日 · We illustrate the distributions of mutation frequencies, types and contexts across tumour types, and establish their links to tissues of origin, environmental/carcinogen influences, and DNA...
A compendium of mutational cancer driver genes - PubMed
2020年8月20日 · In this Review, we present the Integrative OncoGenomics (IntOGen) pipeline, an implementation of such an approach to obtain the compendium of mutational cancer drivers. Its application to somatic mutations of more than 28,000 tumours of 66 cancer types reveals 568 cancer genes and points towards their mechanisms of tumorigenesis.
Mapping Cancer Genomic Evolution - NCI - National Cancer …
2020年3月6日 · In a new international study, researchers used whole-genome sequencing to map the alterations that most frequently drive 38 cancer types. The study, which was published February 6 in Nature, was also able to pinpoint when many of these alterations occurred, both relative to each other and chronologically, over years or decades.
How Does Cancer Start? Genes and Cancer - American Cancer Society
Mutations are abnormal changes in the DNA of a gene and can sometimes lead to cancer. Find out common causes. The main types of genes that play a role in cancer are oncogenes, tumor suppressor genes, and DNA repair genes. Learn more here.