2023年10月17日 · Canonical (conforming to a general rule or acceptable procedure) often refers to established pathways with typical or standard characteristics in biological investigation. A non-canonical (not sanctioned by a canon) feature is one that scientists discover in an established pathway but which does not conform (keep to) to the canonical model.

2012年8月1日 · As much as I know, the canonical pathway means which signaling pathway is constitutively active (naturally occurring inside the body, cells, or tissue). Non-canonical pathway means inducible...

In this study, DKK-1 modulated non-canonical Wnt/PCP–Rac-JNK1 signaling in immune cells while it inhibited the canonical Wnt pathway in osteoblasts to promote metastasis.

2018年4月3日 · As I understand, non-canonical pathways are those that deviate from the canonical paradigm, or that derive to alternative biogenesis pathways and only partially meet the classical defnition. Sometimes non-canonical pathways are those which are alternative less known pathways.

2024年1月1日 · Wnt signaling can be categorized into two pathways, the β-catenin-dependent pathway (canonical) and the β-catenin-independent pathway (noncanonical). 1516 The canonical pathway is important for inducing cell proliferation, differentiation, and maturation. 16 It is also vital in producing proper body-axis specifications. 17 The pathway is activat...

Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis.

Canonical Wnt signaling that is dependent on β-catenin regulates the patterning of dorsoventral, anteroposterior, and left–right axes. Non-canonical Wnt signaling that is independent of β-catenin modulates cytoskeletal organization to coordinate cell …

Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear.

In this review, canonical versus non-canonical JAK-STAT signaling and the implications for gene regulation and cancer formation are discussed. Aberrant activation of the JAK-STAT pathway has been implicated in many human cancers.

Aberrant canonical and non-canonical WNT signaling in human malignancies, including breast, colorectal, gastric, lung, ovary, pancreatic, prostate and uterine cancers, leukemia and melanoma, are involved in CSC survival, bulk-tumor expansion and invasion/metastasis.