Carboplatin - Wikipedia
Mechanism of action [ edit ] Carboplatin differs from cisplatin in that it has a bidentate dicarboxylate (the ligand is cyclobutane dicarboxylate, CBDCA) in place of the two chloride ligands .
Carboplatin: Uses, Interactions, Mechanism of Action
Carboplatin predominantly acts by attaching alkyl groups to the nucleotides, leading to the formation of monoadducts, and DNA fragmenting when repair enzymes attempt to correct the error. 4,9 2% of carboplatin's activity comes from DNA cross-linking from a base on one strand to a base on another, preventing DNA strands from separating for ...
CARBOplatin: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Mechanism of Action. Carboplatin is a platinum compound alkylating agent which covalently binds to DNA; interferes with the function of DNA by producing interstrand DNA cross-links. Carboplatin is apparently not cell-cycle specific. Pharmacokinetics/Pharmacodynamics Distribution
Understanding how the platinum anticancer drug carboplatin …
2012年7月1日 · In this manuscript we review the literature pertaining to the mechanism of action of the front line anticancer drug carboplatin with emphasis of its high stability in aqueous formulations and its activation by carbonate and other substances in the biological system.
Carboplatin - LiverTox - NCBI Bookshelf - National Center for ...
2020年9月15日 · Carboplatin is an intravenously administered platinum coordination complex and alkylating agent which is used as a chemotherapeutic agent for the treatment of various cancers, mainly ovarian, head and neck and lung cancers.
Carboplatin - an overview | ScienceDirect Topics
Carboplatin is a cisplatin-related compound in which the chloride-leaving groups have been substituted, leading to diminished nephrotoxicity but otherwise similar mechanism of action, antitumor activity, and adverse effects. The indications of carboplatin are similar to cisplatin.
Carboplatin - an overview | ScienceDirect Topics
Mechanism of Action. Carboplatin is a platinum-containing compound. Its mechanism of action is through binding within and between DNA strands, thereby inhibiting protein synthesis in a cell cycle phase–nonspecific manner. Carboplatin is eliminated in the urine. Dosage and Indications
Carboplatin Pharmacology - News-Medical.net
2023年6月19日 · Mechanism of action. Carboplatin undergoes activation inside cells and forms reactive platinum complexes that cause the intra- and inter-strand cross-linkage of DNA molecules within the...
Carboplatin: molecular mechanisms of action associated with ...
Detailed mechanisms of action for the three platinating agents are provided, going beyond their nuclear effects to include their cytoplasmic impact within cancer cells.
SciELO - Brasil - Carboplatin: molecular mechanisms of action ...
The aim of this narrative review was to discuss some of the known molecular mechanisms involved in the absorption, metabolism, detoxification, and resistance to platinum-based drugs, especially carboplatin. MECHANISM OF ACTION. To …