2022年11月24日 · The seemingly unlimited potential of cell engineering includes creating alternatives to common drug or gene-based therapeutics; devising improved strategies against cancer, inflammatory diseases, and other maladies; designing tissue regeneration and repair options; exploring the intricate dimensions of human development; and enhancing our ...

In this study, we explored the factors affecting electro-transfection outcomes and developed an optimized DNA electroporation strategy appropriate for T cell engineering and for application in CAR-T cell immunotherapy.

2018年1月30日 · Our investigation of DNA electro-transfection for the use in human primary T cell engineering established and validated an optimized method for the construction of functional CAR-T cells.

Bringing together researchers who aim to engineer cells to improve human health, the Institute provides a multidisciplinary environment at the Johns Hopkins University School of Medicine that stimulates collaboration in hopes of accelerating progress.

Cellular engineering of bacteria, fungi, insect cells and mammalian cells is a promising methodology to improve recombinant protein production for structural, biochemical, and commercial applications.

2022年11月24日 · How can we learn to program cells so that they carry out useful functions with the same degree of precision and reliability as naturally evolved cells? How can we expand the range of therapeutic problems to which cell engineering can be …

Engineering immune cells. Immune cells are responsible for major defensive functions against infectious diseases and cancer. They have the ability to migrate to disease loci, secrete immunomodulatory molecules, and lyse target cells. Engineering of these features for novel applications is a highly promising direction of ongoing research.

Here we condense >130 reviews and key studies in the art into a meta-review of cell factory engineering. We identified 33 generic strategies in the field, all applicable to multiple types of cells and products, and proven successful in multiple major cell types.

Cell Engineering Connect is a dynamic, peer-reviewed, open-access journal dedicated to advancing the frontiers of cell engineering. Published biannually in both print and online formats, the journal provides a platform for cutting-edge research across a wide range of topics, including genetic engineering, stem cell technologies, cell-based ...

2024年4月23日 · Yet, cell engineering is more than just tinkering with cells; the concept suggests a degree of control for a biological or biomedical purpose. In genome engineering, genes are introduced,...