Cerebral organoid - Wikipedia
Neural organoids are created by culturing pluripotent stem cells into a three-dimensional culture that can be maintained for years. [1][2] The brain is an extremely complex system of heterogeneous tissues and consists of a diverse array of neurons and glial cells.
Human cerebral organoids — a new tool for clinical neurology
2022年10月17日 · Organoids are 3D human cell culture models that originate from pluripotent stem cells and recapitulate the hallmarks of human neurodevelopment, enabling studies of human brain development...
Cerebral organoids model human brain development and …
2013年8月28日 · Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain...
A beginner’s guide on the use of brain organoids for …
2023年4月15日 · Human brain organoids are self-assembled three-dimensional (3D) tissue models derived from pluripotent stem cells (PSC) that recapitulate certain aspects of human brain development and physiology [14, 15, 16], including specific cell types and brain regions.
Cerebral organoids model human brain development and …
We have developed a human pluripotent stem cell-derived 3D organoid culture system, termed cerebral organoid, which develops various discrete though interdependent brain regions. These include cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes.
Generation and long-term culture of advanced cerebral organoids …
2020年12月16日 · Cerebral organoids, or brain organoids, can be generated from a wide array of emerging technologies for modeling brain development and disease. The fact that they are cultured in vitro...
Cerebral organoids model human brain development and …
2013年9月19日 · Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions. These include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes.
Establishing Cerebral Organoids as Models of Human-Specific …
Direct comparisons of human and non-human primate brains can reveal molecular pathways underlying remarkable specializations of the human brain. However, chimpanzee tissue is inaccessible during neocortical neurogenesis when differences in brain size first appear.
Applications of brain organoids in neurodevelopment and …
2021年4月22日 · Recent publications have reported that brain organoids can mimic the dynamic spatiotemporal process of early brain development, model various human brain disorders, and serve as an effective preclinical platform to test and guide personalized treatment.
Past, Present, and Future of Brain Organoid Technology - PMC
Brain organoids are organ-like three-dimensional (3D) tissue cultures containing brain-specific cell types derived from PSCs (Lancaster and Knoblich, 2014; Qian et al., 2019).