The example of IgSF molecule is one of the most important co-stimulatory molecules expressed on T cells, CD28, which interacts predominantly with CD80 (B7.1) and CD86 (B7.2), but also with B7-H2 in humans, present on the membrane of activated APCs.

a|Co-stimulatory molecules deliver positive signals to T cells following their engagement by ligands and counter-receptors on antigen-presenting cells (APCs). Several co-stimulatory molecule interactions are bidirectional.

2013年3月8日 · Co-stimulatory and co-inhibitory molecules constitute important targets for immune modulation and the treatment of human diseases. Co-stimulatory and co-inhibitory receptors have a pivotal role...

Co-stimulatory molecules are a heterogenous group of cell surface molecules that act to amplify or counteract the initial activating signals provided to T cells from the T cell receptor (TCR) following its interaction with an antigen/major ...

The classic co-stimulatory molecules are CD28 on the T-lymphocyte, engaged with B7 family members on the APC. Alternatively, engagement of B7 family members by cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on the T-lymphocyte negatively regulates T cell …

2020年9月16日 · Here, we review the targeting of co-stimulatory molecules in autoimmune diseases, focusing in particular on agents directed at members of the CD28 or tumour necrosis factor receptor families.

Co-stimulatory molecules help to regulate interactions between T cells and antigen-presenting cells and may play an important role in the pathogenesis of lupus. Both work in murine models and some early studies in human lupus support further examination of these molecules as therapeutic targets.

Co-stimulatory receptor-ligand pairs in the initiation of a T-cell response. CD27 and CD28 are co-stimulatory molecules that are constitutively expressed. Their ligands CD70, CD80, and CD86 are inducible on dendritic cells upon their activation.

Costimulatory molecules are a heterogenous group of cell surface molecules that act to amplify or counteract the initial activating signals provided to T cells from the T cell receptor following its interaction with an antigen/major histocompatibility complex, thereby influencing T cell differentiat …

Co-stimulatory and co-inhibitory receptors are major modulators of the immune response in health and disease. Zhang and Vignali review our current understanding of the impact of co-stimulatory and co-inhibitory receptors in four emblematic autoimmune diseases and outline the challenges of developing effective therapies for such diseases.