Collagenase - Wikipedia
Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs. [1]
Collagenase - an overview | ScienceDirect Topics
Collagenase is a therapeutic enzyme involved in the cleavage of peptide bonds found in collagen. Collagenase is a Zn2+ -dependent matrix metalloproteinase that is a fundamental component of the extracellular matrix (ECM). It features a saddle-shaped tertiary structure, and the active site contains a zinc moiety.
Collagenase Enzymes: History, Applications, and Mechanisms of …
Since their initial discovery in the 1950s, collagenase enzymes now play a key role in modern scientific research. They have also been approved for therapeutic use when aiming to treat Peyronie's disease and Dupuytren's, and also actively support wound healing.
Tissue Dissociation Guide: Collagenase, Dispase, and Liberase Enzyme …
Collagenases are, enzymes that break down the native collagen that holds animal tissues together and, are made by a variety of microorganisms and by many different animal cells 1. The most potent collagenase is the "crude" collagenase secreted by the anaerobic bacteria Clostridium histolyticum.
Collagenase - an overview | ScienceDirect Topics
Collagenase is an enzyme that catalyzes the breakdown of collagen, the primary component of the dense, fibrotic PD plaque and, therefore, appears to be a sensible injectable agent to lyse the collagen types I and III found in PD plaques.
Unlocking the Potential of Collagenases: Structures, Functions, and ...
2024年10月8日 · Collagenase, an enzyme that digests peptide chains, specifically recognizes the Pro-X-Gly-Pro sequence and cleaves the peptide bond between an amino acid (X) and glycine (Gly).
Collagenase - an overview | ScienceDirect Topics
Collagenase refers to an enzyme that has the ability to break down triple-helical collagen. It is also known as PMNL-collagenase or neutrophil collagenase, and is a member of the matrixin family, specifically matrix metalloproteinase 8 (MMP-8).
Microbial collagenases: an updated review on their …
5 天之前 · This article describes microbial collagenases, providing an introduction to the structure, physiological characteristics, factors affecting enzyme activity, and hydrolysis mechanisms of various classes of these enzymes. Microbial collagenase is the most widely used class of collagenase and plays an important role in all aspects of human life ...
Collagenase: a key enzyme in collagen turnover - PubMed
The collagenases are the enzymes necessary to initiate collagen turnover in normal connective tissue turnover and in disease. The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases that degrade collagen and proteoglycan.
Bacterial collagenases and collagen-degrading enzymes and their ...
Bacterial collagenases and collagen-degrading enzymes and their potential role in human disease. 1 School of Health Sciences, University of Sunderland, United Kingdom. The Full Text of this article is available as a PDF (226.8 KB). These references are in PubMed. This may not be the complete list of references from this article.