Concanavalin A - Wikipedia
Concanavalin A (ConA) is a lectin (carbohydrate -binding protein) originally extracted from the jack-bean (Canavalia ensiformis). It is a member of the legume lectin family.
Concanavalin A as a promising lectin-based anti-cancer agent: …
2022年10月26日 · Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism.
Concanavalin A | ConA Lectin for Lymphocyte Stimulation
Concanavalin A (ConA) is a lymphocyte mitogen that triggers TCR complex cross-linking leading to T cell activation. ConA lectin activates NFAT and is a control for reporter assay using Jurkat-Lucia™ NFAT cells.
Structure and Function of Concanavalin A | SpringerLink
In conjuntion with our studies on the cell surface and mitosis, we have determined the amino acid sequence and three-dimensional struction of concanavalin A (Con A), the mitogenic lectin from the jack bean.
Concanavalin A - SpringerLink
Book Title: Concanavalin A. Editors: Tushar K. Chowdhury, A. Kurt Weiss. Series Title: Advances in Experimental Medicine and Biology. DOI: https://doi.org/10.1007/978-1-4684-0949-9. Publisher: Springer New York, NY. eBook Packages: Springer Book Archive
Concanavalin A (Con A), a mannose/glucose-binding lectin isolated from Jack beans (Canavalia ensiformis), is a well-known T cell mitogen that can activate the immune system, recruit lymphocytes and elicit cytokine production1.
Concanavalin A (Con A) is the most widely used of the plant agglutinins for research in cell biology. Con A was first isolated from the jack bean by Sumner (1919), and was subsequently shown to agglutinate erythrocytes (Sumner and Howell, 1935) and to precipi tate various polysaccharides (Sumner and Howell, 1936a). Since the
Concanavalin A as an anti-cancer agent: The molecular …
Concanavalin A (ConA), a lectin found in jack beans, is one such lectin. This lectin binds to several receptors on cancerous and normal cells and thereby triggers signaling cascades that can induce the controlled death of the tumor cells via autophagy or apoptosis or …
Concanavalin A, from an Old Protein to Novel Candidate Anti …
In this review, we mainly focus on analyzing the anti-tumor activities of Concanavalin A (ConA), the first and most typical representative of legume lectin family, and its related mechanisms of cell death implicated in apoptosis and autophagy.
Concanavalin A (ConA) is an antigen independent mitogen and functions as signal one inducer, T cell activation is initiated by recognition of antigen (Ag) leading T cells to polyclonal proliferation.