Pathology Outlines - Paroxysmal nocturnal hemoglobinuria (PNH)
2021年7月19日 · Positive Coombs test, evidence of extravascular rather than intravascular hemolytic anemia (Oxf Med Case Reports 2020;2020:omz125) Various presentations of microangiopathic and macroangiopathic anemia; Sickle cell disease: Vaso-occlusion and vasculopathy with early onset and chronic progression (Intern Emerg Med 2019;14:1051)
Pathology Outlines - DAT negative autoimmune hemolytic anemia
2023年11月28日 · A 55 year old woman with chronic lymphocytic lymphoma (CLL) presented with anemia and reticulocytosis, a negative routine direct antiglobulin test (DAT) for both complement and IgG, a negative red cell antibody screen, elevated lactate dehydrogenase (LDH), severely decreased haptoglobin and indirect hyperbilirubinemia.
Pathology Outlines - Diagnosing hemolytic anemia
2012年10月1日 · Coombs test: detects acquired cases via detection of surface immune complexes; first wash patient's red blood cells, then add antihuman globulin rabbit serum, agglutination implies acquired hemolytic anemia Direct Coombs test: detects antibody attached to red blood cells (above)
Pathology Outlines - Febrile nonhemolytic
2020年8月27日 · Notify blood bank / transfusion medicine service for reaction workup (direct antiglobulin test, visual inspection for hemolysis, etc.) Close observation with frequent vital signs Fever usually self limiting Antipyretics (e.g. acetaminophen) for symptom relief Meperidine for severe reactions with rigors Reference: Lancet 2016;388:2825
Pathology Outlines - Atrophic papulosis
2021年3月12日 · In association with systemic lupus erythematosus: antinuclear antibody titer, anti-dsDNA, Coombs test, complement protein C3, C4, CH50 or immune complex assays (C1q or C3d) May be differentiated from other associated autoimmune disorders by antiphospholipid and anticardiolipin antibodies, rheumatoid factor, anti-Mi2, antitopoisomerase I and ...
Pathology Outlines - Transfusion medicine
Blood bank testing: ABO discrepancies (pending) adsorption studies antibody identification & panel interpretation (pending) automation Coombs test / DAT DAT negative autoimmune hemolytic anemia Donath-Landsteiner test enzyme treatment (pending) neutralization and lectins (pending) pretransfusion testing red blood cell genotyping (pending) warm ...
Pathology Outlines - Case of the week #403
Direct antiglobulin (Coombs) test (DAT) is negative. Diagnosis : Thrombocytopenia and microangiopathic hemolytic anemia and a severe ADAMTS13 deficiency (< 10% normal values), in the absence of anti-ADAMTS13 antibodies, suggest a diagnosis of congenital TTP.
Pathology Outlines - Hemolytic uremic syndrome / thrombotic ...
2024年3月15日 · Negative Coombs test Reference: Clin J Am Soc Nephrol 2018;13:300. Prognostic factors.
Therapy related myeloid neoplasm (therapy related AML)
2023年9月22日 · Additional tests to exclude other underlying causes of cytopenia(s), as clinically appropriate (i.e. vitamin B12, folate and iron, Coombs test, etc.) Reference: Foucar: Diagnostic Pathology - Blood and Bone Marrow, 2nd Edition, 2017
Pathology Outlines - Board Review Questions
Leukocyte and platelet counts are within normal limits. Coombs test is positive, at 37C, against all cells in the screen. All of the following are true EXCEPT: The patient has warm autoimmune hemolytic anemia (AIHA) The patient should be worked up for an underlying lymphoma The patients autoantibody is most likely IgM